Chemical characterization and biological effect of collagenous fractions extracted from human glomerular basement membrane and fetal tissues

Chemical characterization and biological effect of collagenous fractions extracted from human glomerular basement membrane and fetal tissues

Pepsin digest extracted fractions from human glomerular basement membranes (HGBM) and placenta were characterized for their chemical composition and tested for their biological activity. We demonstrated that fractions which contained type IV collagen induced cell adhesion and spreading of transforme...

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Veröffentlicht in:Cell biology international reports 1982-06, Vol.6 (6), p.579-589
Hauptverfasser: Gutman, N., Lanson, M., Gerfaux, J., Chany-Fournier, F., Muh, J.P, Chany, C.
Format: Artikel
Sprache:eng
Schlagworte:
Amnion - analysis
Basement Membrane - analysis
Carcinoma
Cell Adhesion - drug effects
Cell Line
Chorion - analysis
Collagen - isolation & purification
Collagen - pharmacology
Epithelium
Female
Fetus
Humans
Kidney Glomerulus - analysis
Molecular Weight
Mouth Neoplasms
Osteosarcoma
Placenta - analysis
Pregnancy
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Zusammenfassung:Pepsin digest extracted fractions from human glomerular basement membranes (HGBM) and placenta were characterized for their chemical composition and tested for their biological activity. We demonstrated that fractions which contained type IV collagen induced cell adhesion and spreading of transformed epithelial cells: Kb (ATCC CCL17). Hep2 (ATCC CCL23), WISH (ATCC CCL25), HOS (TE 85 F5). The experiments reported in this paper suggest a possible involvement of type IV collagen in cell recognition and cell attachment processes.
ISSN:0309-1651
1878-240X
DOI:10.1016/0309-1651(82)90182-5