Protection against foot-and-mouth disease by immunization with a chemically synthesized peptide predicted from the viral nucleotide sequence
Chemically synthesized peptides corresponding to two different regions of the VP1 polypeptide of foot-and-mouth disease virus (FMDV) produced high levels of serotype virus neutralizing antibody in cattle, guinea pigs and rabbits. A single inoculation of one of these peptides protected guinea pigs ag...
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| Veröffentlicht in: | Nature (London) 1982-07, Vol.298 (5869), p.30-33 |
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| container_end_page | 33 |
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| container_issue | 5869 |
| container_start_page | 30 |
| container_title | Nature (London) |
| container_volume | 298 |
| creator | Bittle, J.L Houghten, R.A Alexander, H Shinnick, T.M Sutcliffe, J.G Lerner, R.A Rowlands, D.J Brown, F |
| description | Chemically synthesized peptides corresponding to two different regions of the VP1 polypeptide of foot-and-mouth disease virus (FMDV) produced high levels of serotype virus neutralizing antibody in cattle, guinea pigs and rabbits. A single inoculation of one of these peptides protected guinea pigs against subsequent challenge with the virulent virus. |
| doi_str_mv | 10.1038/298030a0 |
| format | Article |
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| fulltext | fulltext |
| identifier | ISSN: 0028-0836 |
| ispartof | Nature (London), 1982-07, Vol.298 (5869), p.30-33 |
| issn | 0028-0836 1476-4687 |
| language | eng |
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| source | MEDLINE; Nature; Alma/SFX Local Collection |
| subjects | Amino Acid Sequence animal diseases animal health Animals Base Sequence DNA, Recombinant - metabolism Escherichia coli - genetics Foot-and-Mouth Disease - prevention & control foot-and-mouth disease virus Guinea Pigs Immunotherapy Peptides - chemical synthesis Peptides - therapeutic use Plasmids Protein Biosynthesis Rabbits - immunology viral diseases of animals and humans |
| title | Protection against foot-and-mouth disease by immunization with a chemically synthesized peptide predicted from the viral nucleotide sequence |
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