Protection against foot-and-mouth disease by immunization with a chemically synthesized peptide predicted from the viral nucleotide sequence

Protection against foot-and-mouth disease by immunization with a chemically synthesized peptide predicted from the viral nucleotide sequence

Chemically synthesized peptides corresponding to two different regions of the VP1 polypeptide of foot-and-mouth disease virus (FMDV) produced high levels of serotype virus neutralizing antibody in cattle, guinea pigs and rabbits. A single inoculation of one of these peptides protected guinea pigs ag...

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Veröffentlicht in:Nature (London) 1982-07, Vol.298 (5869), p.30-33
Hauptverfasser: Bittle, J.L, Houghten, R.A, Alexander, H, Shinnick, T.M, Sutcliffe, J.G, Lerner, R.A, Rowlands, D.J, Brown, F
Format: Artikel
Sprache:eng
Schlagworte:
Amino Acid Sequence
animal diseases
animal health
Animals
Base Sequence
DNA, Recombinant - metabolism
Escherichia coli - genetics
Foot-and-Mouth Disease - prevention & control
foot-and-mouth disease virus
Guinea Pigs
Immunotherapy
Peptides - chemical synthesis
Peptides - therapeutic use
Plasmids
Protein Biosynthesis
Rabbits - immunology
viral diseases of animals and humans
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Zusammenfassung:Chemically synthesized peptides corresponding to two different regions of the VP1 polypeptide of foot-and-mouth disease virus (FMDV) produced high levels of serotype virus neutralizing antibody in cattle, guinea pigs and rabbits. A single inoculation of one of these peptides protected guinea pigs against subsequent challenge with the virulent virus.
ISSN:0028-0836
1476-4687
DOI:10.1038/298030a0