Suppression by essential fatty acids of experimental allergic encephalomyelitis is abolished by indomethacin

Experimental allergic encephalomyelitis to Lewis rats wad puppressed by treatment with essential fatty acids (EFA) given perorally, This treatment effect could be abolished by administration of a drug (Indomethacin) known to inhibit biosynthesis of certain prostaglandins from EFA.This observation su...

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Veröffentlicht in:	Prostaglandins and medicine 1978-10, Vol.1 (4), p.283-291
Hauptverfasser:	Mertin, J., Stackpoole, A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Encephalomyelitis, Autoimmune, Experimental - drug therapy Encephalomyelitis, Autoimmune, Experimental - pathology Fatty Acids, Essential - antagonists & inhibitors Fatty Acids, Essential - therapeutic use Female Indomethacin - pharmacology Male Rats
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Beschreibung
Zusammenfassung:	Experimental allergic encephalomyelitis to Lewis rats wad puppressed by treatment with essential fatty acids (EFA) given perorally, This treatment effect could be abolished by administration of a drug (Indomethacin) known to inhibit biosynthesis of certain prostaglandins from EFA.This observation suggests that the suppressive effect of EFA on cell-mediated immune reactions is brought about by EFA-derived prostaglandins.
ISSN:	0161-4630 1878-0636
DOI:	10.1016/0161-4630(78)90047-2