Platelet studies in patients with hypertrophic cardiomyopathy

Platelet studies in patients with hypertrophic cardiomyopathy

Because of a shared abnormality of platelet and muscle in some neuromuscular diseases, platelets were investigated in five cases of hypertrophic cardiomyopathy, a disease likely to be primarily myogenic. Morphometric and chemical differences from normal were found consisting of increased cell size,...

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Veröffentlicht in:Cardiovascular research 1982-06, Vol.16 (6), p.324-330
Hauptverfasser: YAROM, R, LEWIS, B S, LIJOVETZKY, G, HAVIVI, Y, CHANDLER, J A
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Blood Platelets - metabolism
Blood Platelets - ultrastructure
Calcium - blood
Cardiomyopathy, Hypertrophic - blood
Coronary Disease - blood
Cytoplasm - ultrastructure
Electron Probe Microanalysis
Female
Humans
Male
Microscopy, Electron
Middle Aged
Phosphorus - blood
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Beschreibung
Zusammenfassung:Because of a shared abnormality of platelet and muscle in some neuromuscular diseases, platelets were investigated in five cases of hypertrophic cardiomyopathy, a disease likely to be primarily myogenic. Morphometric and chemical differences from normal were found consisting of increased cell size, decreased phosphorus concentrations and increased permeability to cations. The findings suggest membrane and energy metabolism aberrations.
ISSN:0008-6363
1755-3245
DOI:10.1093/cvr/16.6.324