Bone Marrow Origin of Hepatic Macrophages (Kupffer Cells) in Humans

Bone Marrow Origin of Hepatic Macrophages (Kupffer Cells) in Humans

Hepatic macrophages (Kupffer cells) from two male recipients of bone marrow transplants from females were studied for fluorescent Y body staining and sex chromatin (Barr body). After the transplant, macrophages had the sex karyotype of the donor, indicating that human hepatic macrophages originate i...

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Veröffentlicht in:Science (American Association for the Advancement of Science) 1978-09, Vol.201 (4359), p.937-938
Hauptverfasser: Gale, Robert Peter, Sparkes, Robert S., Golde, David W.
Format: Artikel
Sprache:eng
Schlagworte:
Adolescent
Bacteriophages
Bile
Bird nesting
Bone marrow
Bone Marrow Cells
Bone Marrow Transplantation
Bones
Cell Differentiation
Cell Movement
Female
Graft vs Host Disease - immunology
Humans
Kupffer cells
Kupffer Cells - cytology
Macrophages
Male
Pheromones
Sex chromatin
Transplantation, Homologous
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Beschreibung
Zusammenfassung:Hepatic macrophages (Kupffer cells) from two male recipients of bone marrow transplants from females were studied for fluorescent Y body staining and sex chromatin (Barr body). After the transplant, macrophages had the sex karyotype of the donor, indicating that human hepatic macrophages originate in bone marrow.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.356266