A fluorophotometric study of the effect of topical timolol on aqueous humor dynamics

A modification of the fluorophotometric method of Jones and Maurice is described and used to measure the aqueous flow coefficient. The method was used to measure the effect of topical timolol on aqueous humor dynamics in 15 human subjects. It was found that the acute decrease in intraocular pressure caused by timolol can be explained entirely by its effect on the aqueous flow. The mean aqueous flow coefficient in the timolol treated eye was found to be 0·0126 min −1 before timolol, and 0·0067 min −1 after timolol. A small effect on the aqueous flow coefficient of the untreated eye was also observed.