Prostaglandin-norepinephrine interaction in guinea pig longitudinal muscle
Norepinephrine block of electrically induced contractions of the guinea pig longitudinal muscle-myenteric plexus preparation reverses spontaneously. PGE 1 or E 2 fails to alter rate of reversal in the presence of ascorbic acid but increases the rate in its absence. Using spectrophotometry, it could...
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| Veröffentlicht in: | Life sciences (1973) 1978-07, Vol.23 (1), p.11-16 |
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| container_title | Life sciences (1973) |
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| creator | Ehrenpreis, S. Greenberg, J. Comaty, J.E. |
| description | Norepinephrine block of electrically induced contractions of the guinea pig longitudinal muscle-myenteric plexus preparation reverses spontaneously. PGE
1 or E
2 fails to alter rate of reversal in the presence of ascorbic acid but increases the rate in its absence. Using spectrophotometry, it could be demonstrated that PGE
1 or E
2 significantly increases the rate of autoxidation of norepinephrine, thereby accounting for the pharmacological interaction observed. |
| doi_str_mv | 10.1016/0024-3205(78)90318-1 |
| format | Article |
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1 or E
2 fails to alter rate of reversal in the presence of ascorbic acid but increases the rate in its absence. Using spectrophotometry, it could be demonstrated that PGE
1 or E
2 significantly increases the rate of autoxidation of norepinephrine, thereby accounting for the pharmacological interaction observed.</description><identifier>ISSN: 0024-3205</identifier><identifier>EISSN: 1879-0631</identifier><identifier>DOI: 10.1016/0024-3205(78)90318-1</identifier><identifier>PMID: 682860</identifier><language>eng</language><publisher>Netherlands: Elsevier Inc</publisher><subject>Animals ; Ascorbic Acid - pharmacology ; Electric Stimulation ; Guinea Pigs ; Ileum - physiology ; In Vitro Techniques ; Muscle Contraction - drug effects ; Muscle, Smooth - drug effects ; Norepinephrine - metabolism ; Norepinephrine - pharmacology ; Oxidation-Reduction ; Prostaglandins E - pharmacology</subject><ispartof>Life sciences (1973), 1978-07, Vol.23 (1), p.11-16</ispartof><rights>1978</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c356t-425d1b906f7dc84d8d6384ba57909f85c80fa04962735e67880f903c72904d1d3</citedby><cites>FETCH-LOGICAL-c356t-425d1b906f7dc84d8d6384ba57909f85c80fa04962735e67880f903c72904d1d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0024-3205(78)90318-1$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,45974</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/682860$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ehrenpreis, S.</creatorcontrib><creatorcontrib>Greenberg, J.</creatorcontrib><creatorcontrib>Comaty, J.E.</creatorcontrib><title>Prostaglandin-norepinephrine interaction in guinea pig longitudinal muscle</title><title>Life sciences (1973)</title><addtitle>Life Sci</addtitle><description>Norepinephrine block of electrically induced contractions of the guinea pig longitudinal muscle-myenteric plexus preparation reverses spontaneously. PGE
1 or E
2 fails to alter rate of reversal in the presence of ascorbic acid but increases the rate in its absence. Using spectrophotometry, it could be demonstrated that PGE
1 or E
2 significantly increases the rate of autoxidation of norepinephrine, thereby accounting for the pharmacological interaction observed.</description><subject>Animals</subject><subject>Ascorbic Acid - pharmacology</subject><subject>Electric Stimulation</subject><subject>Guinea Pigs</subject><subject>Ileum - physiology</subject><subject>In Vitro Techniques</subject><subject>Muscle Contraction - drug effects</subject><subject>Muscle, Smooth - drug effects</subject><subject>Norepinephrine - metabolism</subject><subject>Norepinephrine - pharmacology</subject><subject>Oxidation-Reduction</subject><subject>Prostaglandins E - pharmacology</subject><issn>0024-3205</issn><issn>1879-0631</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1978</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kElPwzAUhC3EVgr_oIecEBwCz4nj5YKEKlZVggOcLdd2glE27ASJf49Lqh652H5-MyPNh9ACwxUGTK8BMpLmGRQXjF8KyDFP8R6aYc5ECjTH-2i2kxyjkxA-AaAoWH6EDinPOIUZen71XRhUVavWuDZtO29719r-w8czce1gvdKD69r4Tqoxfqqkd1VSd23lhjF6VJ00Y9C1PUUHpaqDPdvec_R-f_e2fExXLw9Py9tVqvOCDinJCoPXAmjJjObEcENzTtaqYAJEyQvNoVRABM1YXljKeJxjOc0yAcRgk8_R-ZTb--5rtGGQjQva1rGC7cYgGcFZRgSLQjIJdewYvC1l712j_I_EIDcE5QaP3OCRjMs_ghJH22KbP64ba3amCVlc30xrGzt-O-tl0M622hrnrR6k6dz_-b9Lcn9v</recordid><startdate>19780703</startdate><enddate>19780703</enddate><creator>Ehrenpreis, S.</creator><creator>Greenberg, J.</creator><creator>Comaty, J.E.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19780703</creationdate><title>Prostaglandin-norepinephrine interaction in guinea pig longitudinal muscle</title><author>Ehrenpreis, S. ; Greenberg, J. ; Comaty, J.E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c356t-425d1b906f7dc84d8d6384ba57909f85c80fa04962735e67880f903c72904d1d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1978</creationdate><topic>Animals</topic><topic>Ascorbic Acid - pharmacology</topic><topic>Electric Stimulation</topic><topic>Guinea Pigs</topic><topic>Ileum - physiology</topic><topic>In Vitro Techniques</topic><topic>Muscle Contraction - drug effects</topic><topic>Muscle, Smooth - drug effects</topic><topic>Norepinephrine - metabolism</topic><topic>Norepinephrine - pharmacology</topic><topic>Oxidation-Reduction</topic><topic>Prostaglandins E - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ehrenpreis, S.</creatorcontrib><creatorcontrib>Greenberg, J.</creatorcontrib><creatorcontrib>Comaty, J.E.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Life sciences (1973)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ehrenpreis, S.</au><au>Greenberg, J.</au><au>Comaty, J.E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prostaglandin-norepinephrine interaction in guinea pig longitudinal muscle</atitle><jtitle>Life sciences (1973)</jtitle><addtitle>Life Sci</addtitle><date>1978-07-03</date><risdate>1978</risdate><volume>23</volume><issue>1</issue><spage>11</spage><epage>16</epage><pages>11-16</pages><issn>0024-3205</issn><eissn>1879-0631</eissn><abstract>Norepinephrine block of electrically induced contractions of the guinea pig longitudinal muscle-myenteric plexus preparation reverses spontaneously. PGE
1 or E
2 fails to alter rate of reversal in the presence of ascorbic acid but increases the rate in its absence. Using spectrophotometry, it could be demonstrated that PGE
1 or E
2 significantly increases the rate of autoxidation of norepinephrine, thereby accounting for the pharmacological interaction observed.</abstract><cop>Netherlands</cop><pub>Elsevier Inc</pub><pmid>682860</pmid><doi>10.1016/0024-3205(78)90318-1</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0024-3205 |
| ispartof | Life sciences (1973), 1978-07, Vol.23 (1), p.11-16 |
| issn | 0024-3205 1879-0631 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_74122497 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Ascorbic Acid - pharmacology Electric Stimulation Guinea Pigs Ileum - physiology In Vitro Techniques Muscle Contraction - drug effects Muscle, Smooth - drug effects Norepinephrine - metabolism Norepinephrine - pharmacology Oxidation-Reduction Prostaglandins E - pharmacology |
| title | Prostaglandin-norepinephrine interaction in guinea pig longitudinal muscle |
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