Prostaglandin-norepinephrine interaction in guinea pig longitudinal muscle

Norepinephrine block of electrically induced contractions of the guinea pig longitudinal muscle-myenteric plexus preparation reverses spontaneously. PGE 1 or E 2 fails to alter rate of reversal in the presence of ascorbic acid but increases the rate in its absence. Using spectrophotometry, it could...

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Veröffentlicht in:	Life sciences (1973) 1978-07, Vol.23 (1), p.11-16
Hauptverfasser:	Ehrenpreis, S., Greenberg, J., Comaty, J.E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Ascorbic Acid - pharmacology Electric Stimulation Guinea Pigs Ileum - physiology In Vitro Techniques Muscle Contraction - drug effects Muscle, Smooth - drug effects Norepinephrine - metabolism Norepinephrine - pharmacology Oxidation-Reduction Prostaglandins E - pharmacology
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Zusammenfassung:	Norepinephrine block of electrically induced contractions of the guinea pig longitudinal muscle-myenteric plexus preparation reverses spontaneously. PGE 1 or E 2 fails to alter rate of reversal in the presence of ascorbic acid but increases the rate in its absence. Using spectrophotometry, it could be demonstrated that PGE 1 or E 2 significantly increases the rate of autoxidation of norepinephrine, thereby accounting for the pharmacological interaction observed.
ISSN:	0024-3205 1879-0631
DOI:	10.1016/0024-3205(78)90318-1