Influence of Citalopram and Chlorimipramine on Uptake of 5‐HT by Isolated Perfused Guinea Pig Lungs

Influence of Citalopram and Chlorimipramine on Uptake of 5‐HT by Isolated Perfused Guinea Pig Lungs

A method is described for the preparation and perfusion in vitro of isolated guinea pig lungs. 5‐HT is rapidly taken up from a perfusing solution by this organ (about 70% uptake). In the concentration range 10‐7 to 5 × 10‐6 M citalopram concentration dependently inhibited the uptake of 5‐HT by the l...

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Veröffentlicht in:Acta pharmacologica et toxicologica 1978-05, Vol.42 (5), p.377-380
1. Verfasser: Fjalland, B.
Format: Artikel
Sprache:eng
Schlagworte:
5‐HT
Animals
Benzofurans - pharmacology
chlorimipramine
citalopram
Clomipramine - pharmacology
Dibenzazepines - pharmacology
Dose-Response Relationship, Drug
Female
Guinea Pigs
In Vitro Techniques
Isolated perfused lungs
Lung - metabolism
Male
Propylamines - pharmacology
Serotonin - metabolism
Serotonin Antagonists
uptake inhibition
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Beschreibung
Zusammenfassung:A method is described for the preparation and perfusion in vitro of isolated guinea pig lungs. 5‐HT is rapidly taken up from a perfusing solution by this organ (about 70% uptake). In the concentration range 10‐7 to 5 × 10‐6 M citalopram concentration dependently inhibited the uptake of 5‐HT by the lung preparation. Chlorimipramine inhibited the uptake of 5‐HT only by 40–50%, and the inhibition was not concentration dependent. The method used seems to be a reliable model for studying the uptake of 5‐HT.
ISSN:0001-6683
1600-0773
DOI:10.1111/j.1600-0773.1978.tb02220.x