The effect of the route of administration of bacillus Calmette-Guerin on regional immunity

In conclusion, under the conditions of the study, oral BCG caused a significant immunopotentiating effect in mesenteric lymph nodes. During the time period studied, the response was regional. However, the most consistent immunopotentiating effect was that shown by the hind-limb injection of BCG. Although there was a more significant regional response from hind-limb injection, there was also a definite tendency toward systemic immunopotentiation. Intraperitoneal BCG did not produce consistent immunopotentiation.