Regulation of 2–5 A synthetase activity and antiviral state in interferon treated chick cells

Regulation of 2–5 A synthetase activity and antiviral state in interferon treated chick cells

The interferon induced 2′5′ oligoadenylate synthetase activity in chick embryo fibroblasts is transient and decays in the absence of interferon. Inhibition of cell protein synthesis by cycloheximide after removal of IFN prevents this decay; after 2–5 A synthetase activity has decayed, addition of cy...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Biochemical and biophysical research communications 1982-01, Vol.105 (2), p.412-418
Hauptverfasser: Lab, M., Thang, M.N., Soteriadou, K., Koehren, F., Justesen, J.
Format: Artikel
Sprache:eng
Schlagworte:
2',5'-Oligoadenylate Synthetase
Animals
Cells, Cultured
Chick Embryo
Cycloheximide - pharmacology
Fibroblasts - drug effects
Interferons - pharmacology
Nucleotidyltransferases - metabolism
Protein Biosynthesis
Sindbis Virus - drug effects
Time Factors
Virus Replication - drug effects
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:The interferon induced 2′5′ oligoadenylate synthetase activity in chick embryo fibroblasts is transient and decays in the absence of interferon. Inhibition of cell protein synthesis by cycloheximide after removal of IFN prevents this decay; after 2–5 A synthetase activity has decayed, addition of cycloheximide causes recovery and “superinduction” of the 2–5 A synthetase activity. The variations in 2–5 A synthetase activity are correlated with similar variations in antiviral state. These results may be accounted for by translational and post translational regulation of 2–5 A synthetase activity in chick embryo fibroblasts.
ISSN:0006-291X
1090-2104
DOI:10.1016/0006-291X(82)91449-8