delta 9-THC and 17-beta-estradiol in hippocampus

delta 9-THC and 17-beta-estradiol in hippocampus

Electrophysiological field potentials recorded from in vitro hippocampal slice preparations show dose-dependent differences in response to 17-beta-estradiol (E2) and delta-9-tetrahydrocannabinol (THC) added to the incubation medium. Using a wide range of doses (1 pM-10 nM), it was found that mid-ran...

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Veröffentlicht in:Brain research bulletin 1982-04, Vol.8 (4), p.341-345
Hauptverfasser: Foy, M R, Teyler, T J, Vardaris, R M
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Dronabinol - pharmacology
Estradiol - pharmacology
Hippocampus - drug effects
Hippocampus - physiology
In Vitro Techniques
Male
Membrane Potentials - drug effects
Neurons - drug effects
Neurons - physiology
Rats
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Zusammenfassung:Electrophysiological field potentials recorded from in vitro hippocampal slice preparations show dose-dependent differences in response to 17-beta-estradiol (E2) and delta-9-tetrahydrocannabinol (THC) added to the incubation medium. Using a wide range of doses (1 pM-10 nM), it was found that mid-range concentrations of estradiol (100 pM) and THC (10 pM) tended to increase field potentials in CA1 of rodents. Higher dose levels of each agent were found to depress neuronal activity. In the context of prior findings, these results suggest that the two compounds share a common mechanism of action in the hippocampus.
ISSN:0361-9230
DOI:10.1016/0361-9230(82)90070-3