Volume exclusion errors and the determination of serum zinc

Volume exclusion errors and the determination of serum zinc

Volume exclusion gives rise to positive errors in the results of plasma or serum zinc determinations by methods in which protein is precipitated and the zinc extracted into solution. The error is amplified if two extraction steps are employed, and may be +20% or more. The same effects must be expect...

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Veröffentlicht in:Clinica chimica acta 1978-08, Vol.88 (1), p.49-56
Hauptverfasser: Boyde, T.R.C., Wu, S.W.N.
Format: Artikel
Sprache:eng
Schlagworte:
False Positive Reactions
Humans
Mathematics
Solubility
Spectrophotometry, Atomic - methods
Zinc - blood
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Beschreibung
Zusammenfassung:Volume exclusion gives rise to positive errors in the results of plasma or serum zinc determinations by methods in which protein is precipitated and the zinc extracted into solution. The error is amplified if two extraction steps are employed, and may be +20% or more. The same effects must be expected in any analysis involving comparable extraction procedures, whatever the substance being determined.
ISSN:0009-8981
1873-3492
DOI:10.1016/0009-8981(78)90148-1