INTRAGASTRIC ACIDITY, BACTERIA, NITRITE, AND N-NITROSO COMPOUNDS BEFORE, DURING, AND AFTER CIMETIDINE TREATMENT

INTRAGASTRIC ACIDITY, BACTERIA, NITRITE, AND N-NITROSO COMPOUNDS BEFORE, DURING, AND AFTER CIMETIDINE TREATMENT

Eight healthy subjects were studied half-hourly or hourly for 24 h periods before, during, and after cimetidine treatment. No significant differences in intragastric bacterial counts or bacterial species or in intragastric nitrite or N-nitroso-compound concentrations were found as a result of cimeti...

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Veröffentlicht in:The Lancet (British edition) 1982-07, Vol.319 (8281), p.1091-1095
Hauptverfasser: Milton-Thompson, G.J., Ahmet, Z., Lightfoot, N.F., Hunt, R.H., Barnard, J., Brimblecombe, R.W., Moore, P.J., Bavin, P.M.G., Darkin, D.W., Viney, N.
Format: Artikel
Sprache:eng
Schlagworte:
Bacteria - growth & development
Bacteria - metabolism
Cimetidine - pharmacology
Cimetidine - therapeutic use
Guanidines - pharmacology
Humans
Hydrogen-Ion Concentration
Nitrites - metabolism
Nitroso Compounds - metabolism
Peptic Ulcer - drug therapy
Stomach - microbiology
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Zusammenfassung:Eight healthy subjects were studied half-hourly or hourly for 24 h periods before, during, and after cimetidine treatment. No significant differences in intragastric bacterial counts or bacterial species or in intragastric nitrite or N-nitroso-compound concentrations were found as a result of cimetidine treatment. Bacterial counts and nitrite concentrations tended to increase with pH, but N-nitroso-compound concentrations did not. This study provides no evidence that cimetidine treatment may increase the risk of gastric carcinoma by raising N-nitroso-compound concentrations.
ISSN:0140-6736
1474-547X
DOI:10.1016/S0140-6736(82)92277-2