Cysteamine: A Potent and Specific Depletor of Pituitary Prolactin

Cysteamine rapidly reduces the concentration of prolactin in pituitary tissue in vivo and in vitro. The effect is dose-dependent, reversible, and cannot be accounted for by prolactin release. Cysteamine does not appear to exert its effect through dopamine receptors and does not alter lactotrope morp...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 1982-07, Vol.217 (4558), p.452-454
Hauptverfasser:	Millard, W. J., Sagar, S. M., Landis, D. M. D., Martin, J. B., Badger, T. M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amines Animals Anterior pituitary Care and treatment Cells, Cultured Cysteamine Cysteamine - pharmacology Domperidone - pharmacology Dopamine antagonists Dopamine receptors Dosage Dose-Response Relationship, Drug Endocrine diseases Endocrine gland diseases Hormones Hyperprolactinemia Hypothalamus Kinetics Male Physiological aspects Pituitary Gland, Anterior - metabolism Prolactin - analysis Prolactin - metabolism Rats Receptors, Dopamine - physiology Secretion Spiperone - pharmacology Subcutaneous injections Tin
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Beschreibung
Zusammenfassung:	Cysteamine rapidly reduces the concentration of prolactin in pituitary tissue in vivo and in vitro. The effect is dose-dependent, reversible, and cannot be accounted for by prolactin release. Cysteamine does not appear to exert its effect through dopamine receptors and does not alter lactotrope morphology, as determined by electron microscopy.
ISSN:	0036-8075 1095-9203
DOI:	10.1126/science.7089575