Impaired Proliferative Response to B‐Lymphocyte Activators in Common Variable Immunodeficiency
The cell‐mediated immune responses of 39 patients with common variable immunodeficiency (CV1) were studied in vitro, using Staphylococcus aureus and Escherichia coli prepared as whole cells and Candida albicans extract. These microbial activators were found to require intact B‐lymphocyte function fo...
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| Veröffentlicht in: | Scandinavian journal of immunology 1982-03, Vol.15 (3), p.279-286 |
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| container_title | Scandinavian journal of immunology |
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| creator | CUNNINGHAM‐RUNDLES, S. NGHAM‐RUNDLES, C. CUNNI MA, D. I. SIEGAL, F. P. GUPTA, S. SMITHWICK, E. M. KOSLOFF, C. GOOD, R. A. |
| description | The cell‐mediated immune responses of 39 patients with common variable immunodeficiency (CV1) were studied in vitro, using Staphylococcus aureus and Escherichia coli prepared as whole cells and Candida albicans extract. These microbial activators were found to require intact B‐lymphocyte function for normal proliferative response. The patient group was observed to have significantly depressed lymphocyte responses compared with those of controls studied in parallel (P |
| doi_str_mv | 10.1111/j.1365-3083.1982.tb00650.x |
| format | Article |
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CUNNI ; MA, D. I. ; SIEGAL, F. P. ; GUPTA, S. ; SMITHWICK, E. M. ; KOSLOFF, C. ; GOOD, R. A.</creator><creatorcontrib>CUNNINGHAM‐RUNDLES, S. ; NGHAM‐RUNDLES, C. CUNNI ; MA, D. I. ; SIEGAL, F. P. ; GUPTA, S. ; SMITHWICK, E. M. ; KOSLOFF, C. ; GOOD, R. A.</creatorcontrib><description>The cell‐mediated immune responses of 39 patients with common variable immunodeficiency (CV1) were studied in vitro, using Staphylococcus aureus and Escherichia coli prepared as whole cells and Candida albicans extract. These microbial activators were found to require intact B‐lymphocyte function for normal proliferative response. The patient group was observed to have significantly depressed lymphocyte responses compared with those of controls studied in parallel (P<0.01). Negative lymphocyte response to one activator and strongly positive response to another were found in individual patients. Examination of patients’ lymphocyte response to S. aureus and E. coli in association with serum IgG levels demonstrated that a rough correlation could be drawn, showing that patients with serum IgG < 125 mg/dl had markedly lower (P<0.01) lymphocyte responses than those with serum IgG > 300mg/dl. No similar correlation with phytohaemagglutinin activation was observed. Since depressed lymphocyte responses did not correlate with reduced B‐cell number in these patients, intrinsic B‐lymphocyte deficiency was indicated. These preparations of microbial activators are potentially useful tools in exploring lymphocyte subpopulation functions in primary immunodeficiency diseases.</description><identifier>ISSN: 0300-9475</identifier><identifier>EISSN: 1365-3083</identifier><identifier>DOI: 10.1111/j.1365-3083.1982.tb00650.x</identifier><identifier>PMID: 7046032</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adolescent ; Adult ; Aged ; B-Lymphocytes - immunology ; Candida albicans ; Candida albicans - immunology ; Child ; Child, Preschool ; Escherichia coli ; Escherichia coli - immunology ; Humans ; Immunoglobulin G - analysis ; Immunologic Deficiency Syndromes - immunology ; In Vitro Techniques ; Leukocyte Count ; Lymphocyte Activation ; Middle Aged ; Staphylococcus aureus - immunology</subject><ispartof>Scandinavian journal of immunology, 1982-03, Vol.15 (3), p.279-286</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3159-5eccaf3a7227fbc93e20bc813cb45da02e2cc9eedb284e440d42e38f538e0f463</citedby><cites>FETCH-LOGICAL-c3159-5eccaf3a7227fbc93e20bc813cb45da02e2cc9eedb284e440d42e38f538e0f463</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1365-3083.1982.tb00650.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1365-3083.1982.tb00650.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7046032$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>CUNNINGHAM‐RUNDLES, S.</creatorcontrib><creatorcontrib>NGHAM‐RUNDLES, C. CUNNI</creatorcontrib><creatorcontrib>MA, D. I.</creatorcontrib><creatorcontrib>SIEGAL, F. P.</creatorcontrib><creatorcontrib>GUPTA, S.</creatorcontrib><creatorcontrib>SMITHWICK, E. M.</creatorcontrib><creatorcontrib>KOSLOFF, C.</creatorcontrib><creatorcontrib>GOOD, R. A.</creatorcontrib><title>Impaired Proliferative Response to B‐Lymphocyte Activators in Common Variable Immunodeficiency</title><title>Scandinavian journal of immunology</title><addtitle>Scand J Immunol</addtitle><description>The cell‐mediated immune responses of 39 patients with common variable immunodeficiency (CV1) were studied in vitro, using Staphylococcus aureus and Escherichia coli prepared as whole cells and Candida albicans extract. These microbial activators were found to require intact B‐lymphocyte function for normal proliferative response. The patient group was observed to have significantly depressed lymphocyte responses compared with those of controls studied in parallel (P<0.01). Negative lymphocyte response to one activator and strongly positive response to another were found in individual patients. Examination of patients’ lymphocyte response to S. aureus and E. coli in association with serum IgG levels demonstrated that a rough correlation could be drawn, showing that patients with serum IgG < 125 mg/dl had markedly lower (P<0.01) lymphocyte responses than those with serum IgG > 300mg/dl. No similar correlation with phytohaemagglutinin activation was observed. Since depressed lymphocyte responses did not correlate with reduced B‐cell number in these patients, intrinsic B‐lymphocyte deficiency was indicated. These preparations of microbial activators are potentially useful tools in exploring lymphocyte subpopulation functions in primary immunodeficiency diseases.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>B-Lymphocytes - immunology</subject><subject>Candida albicans</subject><subject>Candida albicans - immunology</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Escherichia coli</subject><subject>Escherichia coli - immunology</subject><subject>Humans</subject><subject>Immunoglobulin G - analysis</subject><subject>Immunologic Deficiency Syndromes - immunology</subject><subject>In Vitro Techniques</subject><subject>Leukocyte Count</subject><subject>Lymphocyte Activation</subject><subject>Middle Aged</subject><subject>Staphylococcus aureus - immunology</subject><issn>0300-9475</issn><issn>1365-3083</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1982</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkcuO1DAQRS3EaGgGPgHJYsEuofzKgwXS0OLRo5YG8doax6kIt-I4Y6dhsuMT-Ea-hLS6NVs0tanFPbdKupeQ5wxytszLXc5EoTIBlchZXfF8agAKBfntA7K6kx6SFQiArJalekQep7QDYIKX4pyclyALEHxFvm_8aFzEln6MoXcdRjO5n0g_YRrDkJBOgb75-_vPdvbjj2DnCemlXQgzhZioG-g6eB8G-s1EZ5oe6cb7_RBa7Jx1ONj5CTnrTJ_w6WlfkK_v3n5Zf8i21-8368ttZgVTdabQWtMJU3Jedo2tBXJobMWEbaRqDXDk1taIbcMriVJCKzmKqlOiQuhkIS7Ii-PdMYabPaZJe5cs9r0ZMOyTLiWURaHK_4JMKSk51Av46gjaGFKK2OkxOm_irBnoQw96pw9h60PY-tCDPvWgbxfzs9OXfeOxvbOegl_010f9l-txvsdl_flqw8ta_AMciJq2</recordid><startdate>198203</startdate><enddate>198203</enddate><creator>CUNNINGHAM‐RUNDLES, S.</creator><creator>NGHAM‐RUNDLES, C. CUNNI</creator><creator>MA, D. I.</creator><creator>SIEGAL, F. P.</creator><creator>GUPTA, S.</creator><creator>SMITHWICK, E. M.</creator><creator>KOSLOFF, C.</creator><creator>GOOD, R. A.</creator><general>Blackwell Publishing Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7T5</scope><scope>C1K</scope><scope>H94</scope><scope>M7N</scope><scope>7X8</scope></search><sort><creationdate>198203</creationdate><title>Impaired Proliferative Response to B‐Lymphocyte Activators in Common Variable Immunodeficiency</title><author>CUNNINGHAM‐RUNDLES, S. ; NGHAM‐RUNDLES, C. CUNNI ; MA, D. I. ; SIEGAL, F. P. ; GUPTA, S. ; SMITHWICK, E. M. ; KOSLOFF, C. ; GOOD, R. 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A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Impaired Proliferative Response to B‐Lymphocyte Activators in Common Variable Immunodeficiency</atitle><jtitle>Scandinavian journal of immunology</jtitle><addtitle>Scand J Immunol</addtitle><date>1982-03</date><risdate>1982</risdate><volume>15</volume><issue>3</issue><spage>279</spage><epage>286</epage><pages>279-286</pages><issn>0300-9475</issn><eissn>1365-3083</eissn><abstract>The cell‐mediated immune responses of 39 patients with common variable immunodeficiency (CV1) were studied in vitro, using Staphylococcus aureus and Escherichia coli prepared as whole cells and Candida albicans extract. These microbial activators were found to require intact B‐lymphocyte function for normal proliferative response. The patient group was observed to have significantly depressed lymphocyte responses compared with those of controls studied in parallel (P<0.01). Negative lymphocyte response to one activator and strongly positive response to another were found in individual patients. Examination of patients’ lymphocyte response to S. aureus and E. coli in association with serum IgG levels demonstrated that a rough correlation could be drawn, showing that patients with serum IgG < 125 mg/dl had markedly lower (P<0.01) lymphocyte responses than those with serum IgG > 300mg/dl. No similar correlation with phytohaemagglutinin activation was observed. Since depressed lymphocyte responses did not correlate with reduced B‐cell number in these patients, intrinsic B‐lymphocyte deficiency was indicated. These preparations of microbial activators are potentially useful tools in exploring lymphocyte subpopulation functions in primary immunodeficiency diseases.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>7046032</pmid><doi>10.1111/j.1365-3083.1982.tb00650.x</doi><tpages>8</tpages></addata></record> |
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| subjects | Adolescent Adult Aged B-Lymphocytes - immunology Candida albicans Candida albicans - immunology Child Child, Preschool Escherichia coli Escherichia coli - immunology Humans Immunoglobulin G - analysis Immunologic Deficiency Syndromes - immunology In Vitro Techniques Leukocyte Count Lymphocyte Activation Middle Aged Staphylococcus aureus - immunology |
| title | Impaired Proliferative Response to B‐Lymphocyte Activators in Common Variable Immunodeficiency |
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