Impaired Proliferative Response to B‐Lymphocyte Activators in Common Variable Immunodeficiency

The cell‐mediated immune responses of 39 patients with common variable immunodeficiency (CV1) were studied in vitro, using Staphylococcus aureus and Escherichia coli prepared as whole cells and Candida albicans extract. These microbial activators were found to require intact B‐lymphocyte function fo...

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Veröffentlicht in:	Scandinavian journal of immunology 1982-03, Vol.15 (3), p.279-286
Hauptverfasser:	CUNNINGHAM‐RUNDLES, S., NGHAM‐RUNDLES, C. CUNNI, MA, D. I., SIEGAL, F. P., GUPTA, S., SMITHWICK, E. M., KOSLOFF, C., GOOD, R. A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged B-Lymphocytes - immunology Candida albicans Candida albicans - immunology Child Child, Preschool Escherichia coli Escherichia coli - immunology Humans Immunoglobulin G - analysis Immunologic Deficiency Syndromes - immunology In Vitro Techniques Leukocyte Count Lymphocyte Activation Middle Aged Staphylococcus aureus - immunology
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Zusammenfassung:	The cell‐mediated immune responses of 39 patients with common variable immunodeficiency (CV1) were studied in vitro, using Staphylococcus aureus and Escherichia coli prepared as whole cells and Candida albicans extract. These microbial activators were found to require intact B‐lymphocyte function for normal proliferative response. The patient group was observed to have significantly depressed lymphocyte responses compared with those of controls studied in parallel (P
ISSN:	0300-9475 1365-3083
DOI:	10.1111/j.1365-3083.1982.tb00650.x