Possible Tumor Localization of Tc-99m-Labeled Liposomes: Effects of Lipid Composition, Charge, and Liposome Size

Possible Tumor Localization of Tc-99m-Labeled Liposomes: Effects of Lipid Composition, Charge, and Liposome Size

The possible in vivo distribution of liposomes after they have been directly labeled with Tc-99m has been studied in rats bearing the Walker 256 carcinoma. The importance of lipid composition, charge, and size of liposome were studied with respect to possible tumor-localizing properties. Tumor uptak...

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Veröffentlicht in:The Journal of nuclear medicine (1978) 1978-09, Vol.19 (9), p.1049-1054
Hauptverfasser: Richardson, Vernon J, Jeyasingh, K, Jewkes, R. F, Ryman, Brenda E, Tattersall, M. H. N
Format: Artikel
Sprache:eng
Schlagworte:
Amines
Animals
Carcinoma 256, Walker - diagnosis
Carcinoma 256, Walker - metabolism
Cholesterol
Liposomes - metabolism
Phosphatidic Acids
Phosphatidylcholines
Rats
Technetium - metabolism
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Zusammenfassung:The possible in vivo distribution of liposomes after they have been directly labeled with Tc-99m has been studied in rats bearing the Walker 256 carcinoma. The importance of lipid composition, charge, and size of liposome were studied with respect to possible tumor-localizing properties. Tumor uptake was best with small, fluid-membrane, negatively charged liposomes, as indicated by the distribution of the Tc-99m label. The uptake was visualized on scintigrams.
ISSN:0161-5505
1535-5667