MODIFICATION OF SELDOMYCIN FACTOR 5 AT C-3

MODIFICATION OF SELDOMYCIN FACTOR 5 AT C-3

Attempted removal of the 3'-hydroxyl group of seldomycin factor 5 via displacement of a sulfonate ester has led to 3'-epi-seldomycin factor 5. Removal of the hydroxyl group has been effected by the BARTON procedure. The antibacterial activity of 3'-epi- and 3'-deoxyseldomycin fac...

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Veröffentlicht in:Journal of antibiotics 1978, Vol.31(5), pp.441-450
Hauptverfasser: CARNEY, RONALD E., MCALPINE, JAMES B., JACKSON, MARIANNA, STANASZEK, RUTH S., WASHBURN, WILLIAM H., CIROVIC, MOMIR, MUELLER, SANDRA L.
Format: Artikel
Sprache:eng
Schlagworte:
Anti-Bacterial Agents - chemical synthesis
Anti-Bacterial Agents - pharmacology
Bacteria - drug effects
Hydrolysis
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Zusammenfassung:Attempted removal of the 3'-hydroxyl group of seldomycin factor 5 via displacement of a sulfonate ester has led to 3'-epi-seldomycin factor 5. Removal of the hydroxyl group has been effected by the BARTON procedure. The antibacterial activity of 3'-epi- and 3'-deoxyseldomycin factor 5 against various aminoglycoside-resistant strains is discussed.
ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.31.441