Chromatographic Separation and Assay of Morphine in Tablets
A method specific for the determination of morphine sulfate in tablets was developed. Morphine is separated from the excipient and degradation products by a column chromatographic method. The eluate containing morphine is extracted into an acid solution and determined spectrophotometrically. Recover...
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| Veröffentlicht in: | Journal of pharmaceutical sciences 1978-08, Vol.67 (8), p.1099-1102 |
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| container_end_page | 1102 |
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| container_issue | 8 |
| container_start_page | 1099 |
| container_title | Journal of pharmaceutical sciences |
| container_volume | 67 |
| creator | Holcomb, I.J. Luers, R.B. Fusari, S.A. |
| description | A method specific for the determination of morphine sulfate in tablets was developed. Morphine is separated from the excipient and degradation products by a column chromatographic method. The eluate containing morphine is extracted into an acid solution and determined spectrophotometrically. Recovery from standard solutions is greater than 99%. This method is more specific for the separation and determination of morphine in tablets than is the USP XVIII procedure. |
| doi_str_mv | 10.1002/jps.2600670819 |
| format | Article |
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Morphine is separated from the excipient and degradation products by a column chromatographic method. The eluate containing morphine is extracted into an acid solution and determined spectrophotometrically. Recovery from standard solutions is greater than 99%. This method is more specific for the separation and determination of morphine in tablets than is the USP XVIII procedure.</description><identifier>ISSN: 0022-3549</identifier><identifier>EISSN: 1520-6017</identifier><identifier>DOI: 10.1002/jps.2600670819</identifier><identifier>PMID: 671245</identifier><language>eng</language><publisher>Washington: Elsevier Inc</publisher><subject>chromatographic analysis in tablets ; Chromatography, Thin Layer ; Chromatography-analysis ; Chromatography—analysis, morphine sulfate in tablets ; Methods ; Morphine - analysis ; morphine sulfate in tablets ; Morphine sulfate-chromatographic analysis in tablets ; Narcotic analgesics-morphine sulfate ; Narcotic analgesics—morphine sulfate, chromatographic analysis in tablets ; Spectrophotometry, Ultraviolet ; Tablets - analysis</subject><ispartof>Journal of pharmaceutical sciences, 1978-08, Vol.67 (8), p.1099-1102</ispartof><rights>1978 Wiley-Liss, Inc., A Wiley Company</rights><rights>Copyright © 1978 Wiley‐Liss, Inc., A Wiley Company</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjps.2600670819$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjps.2600670819$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/671245$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Holcomb, I.J.</creatorcontrib><creatorcontrib>Luers, R.B.</creatorcontrib><creatorcontrib>Fusari, S.A.</creatorcontrib><title>Chromatographic Separation and Assay of Morphine in Tablets</title><title>Journal of pharmaceutical sciences</title><addtitle>J. Pharm. Sci</addtitle><description>A method specific for the determination of morphine sulfate in tablets was developed. Morphine is separated from the excipient and degradation products by a column chromatographic method. The eluate containing morphine is extracted into an acid solution and determined spectrophotometrically. Recovery from standard solutions is greater than 99%. This method is more specific for the separation and determination of morphine in tablets than is the USP XVIII procedure.</description><subject>chromatographic analysis in tablets</subject><subject>Chromatography, Thin Layer</subject><subject>Chromatography-analysis</subject><subject>Chromatography—analysis, morphine sulfate in tablets</subject><subject>Methods</subject><subject>Morphine - analysis</subject><subject>morphine sulfate in tablets</subject><subject>Morphine sulfate-chromatographic analysis in tablets</subject><subject>Narcotic analgesics-morphine sulfate</subject><subject>Narcotic analgesics—morphine sulfate, chromatographic analysis in tablets</subject><subject>Spectrophotometry, Ultraviolet</subject><subject>Tablets - analysis</subject><issn>0022-3549</issn><issn>1520-6017</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1978</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkLlPwzAchS3EVY6ViSETW4qPJI7FBOUWl9RKsFmO8wsY0jjYKdD_HqOgIgbEYg_ve0_2h9AOwUOCMd1_bv2QZhhnHOdELKEBSSmOM0z4MhoEgMYsTcQ62vD-GQcMp-kaWs04oUk6QAejJ2enqrOPTrVPRkdjaJVTnbFNpJoyOvRezSNbRdfWhbyByDTRRBU1dH4LrVSq9rD9fW-iyenJZHQeX92eXYwOr2LNwoviqkwYT5OEVQSUgjwvSa51znHCoKwwp1wQRllCBMsF10U4RUaFKkgBQDnbRHv9bOvs6wx8J6fGa6hr1YCdeckTnFGKRQCHPaid9d5BJVtnpsrNJcHyy5UMruSPq1DY_V6eFVMoF3gvJ8Sij99NDfN_xuTl3fjXdNx3je_gY9FV7iWsBx3y_uZMsgfKj47PQzfwec9DEPlmwEmvDTQaSuNAd7K05q9ffAJGhJWT</recordid><startdate>197808</startdate><enddate>197808</enddate><creator>Holcomb, I.J.</creator><creator>Luers, R.B.</creator><creator>Fusari, S.A.</creator><general>Elsevier Inc</general><general>Wiley Subscription Services, Inc., A Wiley Company</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>197808</creationdate><title>Chromatographic Separation and Assay of Morphine in Tablets</title><author>Holcomb, I.J. ; Luers, R.B. ; Fusari, S.A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3819-fd4375443f1eaae88d18cc87043edf0727913234193897cb3899629ab1bee273</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1978</creationdate><topic>chromatographic analysis in tablets</topic><topic>Chromatography, Thin Layer</topic><topic>Chromatography-analysis</topic><topic>Chromatography—analysis, morphine sulfate in tablets</topic><topic>Methods</topic><topic>Morphine - analysis</topic><topic>morphine sulfate in tablets</topic><topic>Morphine sulfate-chromatographic analysis in tablets</topic><topic>Narcotic analgesics-morphine sulfate</topic><topic>Narcotic analgesics—morphine sulfate, chromatographic analysis in tablets</topic><topic>Spectrophotometry, Ultraviolet</topic><topic>Tablets - analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Holcomb, I.J.</creatorcontrib><creatorcontrib>Luers, R.B.</creatorcontrib><creatorcontrib>Fusari, S.A.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of pharmaceutical sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Holcomb, I.J.</au><au>Luers, R.B.</au><au>Fusari, S.A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Chromatographic Separation and Assay of Morphine in Tablets</atitle><jtitle>Journal of pharmaceutical sciences</jtitle><addtitle>J. Pharm. Sci</addtitle><date>1978-08</date><risdate>1978</risdate><volume>67</volume><issue>8</issue><spage>1099</spage><epage>1102</epage><pages>1099-1102</pages><issn>0022-3549</issn><eissn>1520-6017</eissn><abstract>A method specific for the determination of morphine sulfate in tablets was developed. Morphine is separated from the excipient and degradation products by a column chromatographic method. The eluate containing morphine is extracted into an acid solution and determined spectrophotometrically. Recovery from standard solutions is greater than 99%. This method is more specific for the separation and determination of morphine in tablets than is the USP XVIII procedure.</abstract><cop>Washington</cop><pub>Elsevier Inc</pub><pmid>671245</pmid><doi>10.1002/jps.2600670819</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Journal of pharmaceutical sciences, 1978-08, Vol.67 (8), p.1099-1102 |
| issn | 0022-3549 1520-6017 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_74062209 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Alma/SFX Local Collection |
| subjects | chromatographic analysis in tablets Chromatography, Thin Layer Chromatography-analysis Chromatography—analysis, morphine sulfate in tablets Methods Morphine - analysis morphine sulfate in tablets Morphine sulfate-chromatographic analysis in tablets Narcotic analgesics-morphine sulfate Narcotic analgesics—morphine sulfate, chromatographic analysis in tablets Spectrophotometry, Ultraviolet Tablets - analysis |
| title | Chromatographic Separation and Assay of Morphine in Tablets |
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