Chromatographic Separation and Assay of Morphine in Tablets

A method specific for the determination of morphine sulfate in tablets was developed. Morphine is separated from the excipient and degradation products by a column chromatographic method. The eluate containing morphine is extracted into an acid solution and determined spectrophotometrically. Recover...

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Veröffentlicht in:	Journal of pharmaceutical sciences 1978-08, Vol.67 (8), p.1099-1102
Hauptverfasser:	Holcomb, I.J., Luers, R.B., Fusari, S.A.
Format:	Artikel
Sprache:	eng
Schlagworte:	chromatographic analysis in tablets Chromatography, Thin Layer Chromatography-analysis Chromatography—analysis, morphine sulfate in tablets Methods Morphine - analysis morphine sulfate in tablets Morphine sulfate-chromatographic analysis in tablets Narcotic analgesics-morphine sulfate Narcotic analgesics—morphine sulfate, chromatographic analysis in tablets Spectrophotometry, Ultraviolet Tablets - analysis
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Beschreibung
Zusammenfassung:	A method specific for the determination of morphine sulfate in tablets was developed. Morphine is separated from the excipient and degradation products by a column chromatographic method. The eluate containing morphine is extracted into an acid solution and determined spectrophotometrically. Recovery from standard solutions is greater than 99%. This method is more specific for the separation and determination of morphine in tablets than is the USP XVIII procedure.
ISSN:	0022-3549 1520-6017
DOI:	10.1002/jps.2600670819