Glycocinnamoylspermidines, a new class of antibiotics. II. Isolation, physiocochemical and biological properties of LL-BM123beta, gamma1 and gamma2

LL-BM123beta, gamma1 and gamma2 are three new antibiotics produced by fermentation of an unidentified species of Nocardia. These strongly basic, water soluble compounds were isolated from the culture filtrate by CM-Sephadex ion-exchange and carbon chromatography. All three antibiotics are active aga...

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Veröffentlicht in:Journal of antibiotics 1978-05, Vol.31 (5), p.398-404
Hauptverfasser: Martin, J H, Kunstmann, M P, Barbatschi, F, Hertz, M, Ellestad, G A, Dann, M, Redin, G S, Dornbush, A C, Kuck, N A
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Sprache:eng
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Zusammenfassung:LL-BM123beta, gamma1 and gamma2 are three new antibiotics produced by fermentation of an unidentified species of Nocardia. These strongly basic, water soluble compounds were isolated from the culture filtrate by CM-Sephadex ion-exchange and carbon chromatography. All three antibiotics are active against both gram-positive and gram-negative bacteria. A mixture of LL-BM123 gamma1 and gamma2 is more active than the beta component but generally less active than gentamicin.
ISSN:0021-8820