Evaluation of a passive hemagglutination test kit for the detection of rubella antibodies

RUBACELL (Abbott Laboratories), a commercial test kit for the detection of rubella antibodies that utilizes the principle of passive hemagglutination (PHA), was compared with a standard hemagglutination-inhibition (HI) assay procedure. The PHA test gives a qualitative yes/no result suitable for preg...

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Veröffentlicht in:	American journal of clinical pathology 1982-04, Vol.77 (4), p.462-464
Hauptverfasser:	West, D J, Manty, A M, Siem, R A
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies, Viral - analysis Evaluation Studies as Topic False Positive Reactions Hemagglutination Inhibition Tests - methods Hemagglutination Tests - instrumentation Humans Reagent Kits, Diagnostic Rubella - immunology rubella virus
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Beschreibung
Zusammenfassung:	RUBACELL (Abbott Laboratories), a commercial test kit for the detection of rubella antibodies that utilizes the principle of passive hemagglutination (PHA), was compared with a standard hemagglutination-inhibition (HI) assay procedure. The PHA test gives a qualitative yes/no result suitable for pregravidic determination of immune status. The procedure is technically simple and requires less than half the time needed for the HI assay. Four of 61 sera that were negative with HI assay tested as indeterminate or as falsely positive using the RUBACELL procedure.
ISSN:	0002-9173 1943-7722
DOI:	10.1093/ajcp/77.4.462