The Effect of Calcium Dobesilate on Nonproliferative Diabetic Retinopathy: A Controlled Study

Two independent, double-masked, controlled studies were made to evaluate the efficacy of calcium dobesilate for the treatment of nonproliferative diabetic retinopathy. Forty-two patients underwent a six-month crossover evaluation while receiving calcium dobesilate (750 mg per day) and placebo in ran...

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Veröffentlicht in:	Ophthalmology (Rochester, Minn.) Minn.), 1978-06, Vol.85 (6), p.594-606
Hauptverfasser:	Stamper, Robert L., Smith, Morton E., Aronson, Samuel B., Cavender, John C., Cleasby, Gilbert W., Fung, Wayne E., Becker, Bernard
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aneurysm - drug therapy Benzenesulfonates - therapeutic use calcium dobesilate Calcium Dobesilate - pharmacology Calcium Dobesilate - therapeutic use Capillary Fragility - drug effects Clinical Trials as Topic diabetes mellitus Diabetic retinopathy Diabetic Retinopathy - drug therapy Double-Blind Method Exudates and Transudates - drug effects Fluorescein Angiography Humans Placebos Radiography retina Retinal Hemorrhage - drug therapy Retinal Vessels - diagnostic imaging
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Beschreibung
Zusammenfassung:	Two independent, double-masked, controlled studies were made to evaluate the efficacy of calcium dobesilate for the treatment of nonproliferative diabetic retinopathy. Forty-two patients underwent a six-month crossover evaluation while receiving calcium dobesilate (750 mg per day) and placebo in random order. Thirty-six patients received calcium dobesilate (1,000 mg per day) or placebo for one year. Evaluation by clinical examination, fluorescein angiography, and fundus photography failed to demonstrate any beneficial effect of calcium dobesilate.
ISSN:	0161-6420 1549-4713
DOI:	10.1016/S0161-6420(78)35643-8