A mutation affecting the σ subunit of RNA polymerase changes transcriptional specificity
The RNA polymerase mutation, alt-1 , affects the σ subunit and alters the in vitro selectivity of RNA polymerase to parallel the in vivo phenotype. We propose that the mutation changes the distribution of functionally distinct polymerase isomers.
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| Veröffentlicht in: | Nature (London) 1978-06, Vol.273 (5661), p.354-358 |
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| container_end_page | 358 |
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| container_issue | 5661 |
| container_start_page | 354 |
| container_title | Nature (London) |
| container_volume | 273 |
| creator | Travers, Andrew A. Buckland, Robin Goman, M. Le Grice, S. S. G. Scaife, J. G. |
| description | The RNA polymerase mutation,
alt-1
, affects the σ subunit and alters the
in vitro
selectivity of RNA polymerase to parallel the
in vivo
phenotype. We propose that the mutation changes the distribution of functionally distinct polymerase isomers. |
| doi_str_mv | 10.1038/273354a0 |
| format | Article |
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| fulltext | fulltext |
| identifier | ISSN: 0028-0836 |
| ispartof | Nature (London), 1978-06, Vol.273 (5661), p.354-358 |
| issn | 0028-0836 1476-4687 |
| language | eng |
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| source | MEDLINE; Nature; Springer Nature - Complete Springer Journals |
| subjects | Chromosome Mapping DNA-Directed RNA Polymerases - genetics DNA-Directed RNA Polymerases - metabolism Escherichia coli - enzymology Escherichia coli - genetics Genes, Regulator Genetic Linkage Humanities and Social Sciences multidisciplinary Mutation Operon Science Science (multidisciplinary) Sigma Factor - genetics Substrate Specificity Transcription Factors - genetics Transcription, Genetic |
| title | A mutation affecting the σ subunit of RNA polymerase changes transcriptional specificity |
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