A mutation affecting the σ subunit of RNA polymerase changes transcriptional specificity

The RNA polymerase mutation, alt-1 , affects the σ subunit and alters the in vitro selectivity of RNA polymerase to parallel the in vivo phenotype. We propose that the mutation changes the distribution of functionally distinct polymerase isomers.

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Bibliographische Detailangaben
Veröffentlicht in:	Nature (London) 1978-06, Vol.273 (5661), p.354-358
Hauptverfasser:	Travers, Andrew A, Buckland, Robin, Goman, M, Le Grice, S. S. G, Scaife, J. G
Format:	Artikel
Sprache:	eng
Schlagworte:	Chromosome Mapping DNA-Directed RNA Polymerases - genetics DNA-Directed RNA Polymerases - metabolism Escherichia coli - enzymology Escherichia coli - genetics Genes, Regulator Genetic Linkage Humanities and Social Sciences multidisciplinary Mutation Operon Science Science (multidisciplinary) Sigma Factor - genetics Substrate Specificity Transcription Factors - genetics Transcription, Genetic
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Beschreibung
Zusammenfassung:	The RNA polymerase mutation, alt-1 , affects the σ subunit and alters the in vitro selectivity of RNA polymerase to parallel the in vivo phenotype. We propose that the mutation changes the distribution of functionally distinct polymerase isomers.
ISSN:	0028-0836 1476-4687
DOI:	10.1038/273354a0