Biliverdin initiates the liver regeneration in the rat — A hypothesis

Biliverdin has been observed to occur in the blood plasma of a 90% hepatectomized rat. It is also shown that the bile pigment induces a rise in mitotic index in the hepatic parenchymal cells of an intact rat at about 30 h and an elevated rate of hepatic DNA synthesis at 26 h after a single intraperi...

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Veröffentlicht in:	Biochemical and biophysical research communications 1978-03, Vol.81 (2), p.512-520
Hauptverfasser:	Okazaki, Kimihiko, Nishimura, Hisao, Arizono, Hatsuo, Nishimura, Noriko, Suzuki, Yumiko
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bilirubin - analogs & derivatives Bilirubin - pharmacology Biliverdine - pharmacology Biliverdine - physiology DNA - biosynthesis Female Hemoglobins - pharmacology Liver - drug effects Liver - metabolism Liver Regeneration - drug effects Mitotic Index Rats
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Zusammenfassung:	Biliverdin has been observed to occur in the blood plasma of a 90% hepatectomized rat. It is also shown that the bile pigment induces a rise in mitotic index in the hepatic parenchymal cells of an intact rat at about 30 h and an elevated rate of hepatic DNA synthesis at 26 h after a single intraperitoneal injection. Hemoglobin, bilirubin, hemin, and protoporphyrin exhibited some of the inducing activity at lower degrees. It is hypothesized that biliverdin initiates the liver-cell-multiplication.
ISSN:	0006-291X 1090-2104
DOI:	10.1016/0006-291X(78)91564-4