Conformational studies on the enkephalin releasing peptides, Tyr-Arg and Tyr-D-Arg

Conformational studies on the enkephalin releasing peptides, Tyr-Arg and Tyr-D-Arg

Conformational energy calculations were carried out on the enkephalin releasing peptides, Tyr-Arg and Try-D-Arg. The conformations of low energy were found to result in two configurations in which the side-chains were either on opposite sides of the backbone (R1) or parallel to one another (R2). A c...

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Veröffentlicht in:Biochemical and biophysical research communications 1982-04, Vol.105 (3), p.847-854
Hauptverfasser: Manavalan, P., Momany, F.A.
Format: Artikel
Sprache:eng
Schlagworte:
conformational analysis
Dipeptides - pharmacology
Endorphins - metabolism
Enkephalins - metabolism
kyotorphin
mathematical models
Protein Conformation
Thermodynamics
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Zusammenfassung:Conformational energy calculations were carried out on the enkephalin releasing peptides, Tyr-Arg and Try-D-Arg. The conformations of low energy were found to result in two configurations in which the side-chains were either on opposite sides of the backbone (R1) or parallel to one another (R2). A comparison of the two molecules suggests that configuration R2 is most probably the active structure. A method for testing this hypothesis is presented.
ISSN:0006-291X
1090-2104
DOI:10.1016/0006-291X(82)91047-6