THE TOTAL SYNTHESIS OF NOCARDICIN A

We report here a total synthesis of nocardicin A. The antibiotic was obtained as a mixture of diastereoisomers that possessed approximately one quarter of the antibacterial activity of the naturally occurring material.

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Bibliographische Detailangaben
Veröffentlicht in:	Journal of antibiotics 1982, Vol.35(3), pp.329-334
Hauptverfasser:	CURRAN, WILLIAM V., SASSIVER, MARTIN L., ROSS, ADMA S., FIELDS, THOMAS L., BOOTHE, JAMES H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - chemical synthesis Anti-Bacterial Agents - pharmacology Chemical Phenomena Chemistry Lactams - chemical synthesis Lactams - pharmacology Stereoisomerism
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Beschreibung
Zusammenfassung:	We report here a total synthesis of nocardicin A. The antibiotic was obtained as a mixture of diastereoisomers that possessed approximately one quarter of the antibacterial activity of the naturally occurring material.
ISSN:	0021-8820 1881-1469
DOI:	10.7164/antibiotics.35.329