Synthesis of Potential Antineoplastic Agents XXVI: 1,3,4,6,7,11b-Hexahydro-9,10-dimethoxy-2H-benzo[a]2-quinolizinone Derivatives

A number of 3-alkyl-1,3,4,6,7,llb-hexahydro-9,10-dime thoxy-2H-benzo[a] 2-quinolizinones and 2-substituted 3-ethyl-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-2H-benzo[a]quinolizines were prepared and submitted for antineoplastic and anticonvulsant screening.

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of pharmaceutical sciences 1978-06, Vol.67 (6), p.871-873
Hauptverfasser:	Popp, F.D., Watts, R.F.
Format:	Artikel
Sprache:	eng
Schlagworte:	2H-Benzo(a)quinolizin-2-ol, 2-Ethyl-1,3,4,6,7,11b-hexahydro-3-isobutyl-9,10-dimethoxy- - analogs & derivatives 2H-Benzo(a)quinolizin-2-ol, 2-Ethyl-1,3,4,6,7,11b-hexahydro-3-isobutyl-9,10-dimethoxy- - chemical synthesis 2H-Benzo(a)quinolizin-2-ol, 2-Ethyl-1,3,4,6,7,11b-hexahydro-3-isobutyl-9,10-dimethoxy- - pharmacology 2H-Benzo(a)quinolizin-2-ol, 2-Ethyl-1,3,4,6,7,11b-hexahydro-3-isobutyl-9,10-dimethoxy- - therapeutic use Animals Anticonvulsant activity-evaluated in various substituted benzo[a]quinolizines Anticonvulsants - chemical synthesis Antineoplastic activity-evaluated in various substituted benzo[a]quinolizines Antineoplastic Agents - chemical synthesis Antineoplastic Agents - therapeutic use Benzo[a]quinolizines Benzo[a]quinolizines various substituted—synthesized, evaluated for antineoplastic and anticonvulsant activity evaluated for antineoplastic and anticonvulsant activity Leukemia L1210 - drug therapy Leukemia, Experimental - drug therapy Quinolizines - chemical synthesis Structure-activity relationships-various substituted benzo[a]quinolizines evaluated for antineoplastic and anticonvulsant activity various substituted-synthesized
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	A number of 3-alkyl-1,3,4,6,7,llb-hexahydro-9,10-dime thoxy-2H-benzo[a] 2-quinolizinones and 2-substituted 3-ethyl-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-2H-benzo[a]quinolizines were prepared and submitted for antineoplastic and anticonvulsant screening.
ISSN:	0022-3549 1520-6017
DOI:	10.1002/jps.2600670642