Norepinephrine attenuation of amnesia produced by diethyldithiocarbamate

Rats given 680 mg/kg diethyldithiocarbamate, approximately one half hour before training in an inhibitory avoidance task, had impaired retention performance when tested one week after training. Intracerebroventricular or subcutaneous injections of norepinephrine administered shortly after training attenuated the disruptive effects of DDC on retention performance. The effect depended upon the footshock intensity used during training. NE (0.01 μg) administered centrally attenuated the DDC induced retention deficit when animals were trained with a high (2 mA) but not a low footshock (0.5 mA). The effect of peripherally administered NE also varied with the intensity of footshock. The lowest dose of subcutaneously administered NE (5 μg/kg) was effective in attenuating DDC induced retention deficits only when animals were trained with higher footshock. Higher doses of NE (50 μg/kg, 500 μg/kg) were more effective when animals were trained with lower footshock.