Difference Spectrophotometric Determination of p-Hydroxybenzoic Acid in Presence of Its Esters
A difference spectrophotometric analytical method was developed for the selective determination of p-hydroxybenzoic acid in the presence of its alkyl esters without prior separation. Based on the spectral shift to a shorter wavelength accompanying carboxyl dissociation, the procedure measures as lit...
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| Veröffentlicht in: | Journal of pharmaceutical sciences 1978-06, Vol.67 (6), p.837-839 |
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| Format: | Artikel |
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| container_end_page | 839 |
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| container_issue | 6 |
| container_start_page | 837 |
| container_title | Journal of pharmaceutical sciences |
| container_volume | 67 |
| creator | Fink, D.W. Fink, H.C. Tolan, J.W. Blodinger, J. |
| description | A difference spectrophotometric analytical method was developed for the selective determination of p-hydroxybenzoic acid in the presence of its alkyl esters without prior separation. Based on the spectral shift to a shorter wavelength accompanying carboxyl dissociation, the procedure measures as little as 2% of this acid in mixtures with the alkyl ester preservatives and has an accuracy of 2% mean relative error over the 0.16-12.0μg of p-hydroxybenzoic acid/ml range. |
| doi_str_mv | 10.1002/jps.2600670629 |
| format | Article |
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Based on the spectral shift to a shorter wavelength accompanying carboxyl dissociation, the procedure measures as little as 2% of this acid in mixtures with the alkyl ester preservatives and has an accuracy of 2% mean relative error over the 0.16-12.0μg of p-hydroxybenzoic acid/ml range.</description><identifier>ISSN: 0022-3549</identifier><identifier>EISSN: 1520-6017</identifier><identifier>DOI: 10.1002/jps.2600670629</identifier><identifier>PMID: 660470</identifier><language>eng</language><publisher>Washington: Elsevier Inc</publisher><subject>difference-analysis ; Hydroxybenzoates - analysis ; p-hydroxybenzoic acid in presence of alkyl esters ; p-Hydroxybenzoic acid-difference spectrophotometric analysis in presence of alkyl esters ; Spectrophotometry ; Spectrophotometry differenceanalysis, p-hydroxybenzoic acid in presence of alkyl esters ; Spectrophotometry, difference—analysis, p‐hydroxybenzoic acid in presence of alkyl esters ; Spectrophotometry, Ultraviolet - methods</subject><ispartof>Journal of pharmaceutical sciences, 1978-06, Vol.67 (6), p.837-839</ispartof><rights>1978 Wiley-Liss, Inc., A Wiley Company</rights><rights>Copyright © 1978 Wiley‐Liss, Inc., A Wiley Company</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3419-62e788773733d919f0e536b22e0503dfc7d73c1fa8be8a13381174f165c053973</citedby><cites>FETCH-LOGICAL-c3419-62e788773733d919f0e536b22e0503dfc7d73c1fa8be8a13381174f165c053973</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjps.2600670629$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjps.2600670629$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,781,785,1418,27928,27929,45578,45579</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/660470$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fink, D.W.</creatorcontrib><creatorcontrib>Fink, H.C.</creatorcontrib><creatorcontrib>Tolan, J.W.</creatorcontrib><creatorcontrib>Blodinger, J.</creatorcontrib><title>Difference Spectrophotometric Determination of p-Hydroxybenzoic Acid in Presence of Its Esters</title><title>Journal of pharmaceutical sciences</title><addtitle>J. Pharm. Sci</addtitle><description>A difference spectrophotometric analytical method was developed for the selective determination of p-hydroxybenzoic acid in the presence of its alkyl esters without prior separation. Based on the spectral shift to a shorter wavelength accompanying carboxyl dissociation, the procedure measures as little as 2% of this acid in mixtures with the alkyl ester preservatives and has an accuracy of 2% mean relative error over the 0.16-12.0μg of p-hydroxybenzoic acid/ml range.</description><subject>difference-analysis</subject><subject>Hydroxybenzoates - analysis</subject><subject>p-hydroxybenzoic acid in presence of alkyl esters</subject><subject>p-Hydroxybenzoic acid-difference spectrophotometric analysis in presence of alkyl esters</subject><subject>Spectrophotometry</subject><subject>Spectrophotometry differenceanalysis, p-hydroxybenzoic acid in presence of alkyl esters</subject><subject>Spectrophotometry, difference—analysis, p‐hydroxybenzoic acid in presence of alkyl esters</subject><subject>Spectrophotometry, Ultraviolet - methods</subject><issn>0022-3549</issn><issn>1520-6017</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1978</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1P3DAQhq2qX1votacecuot27Ed2_ERLZQPobISbbnVyjpj1XQTBzsLLL8e0yCqHlBPc5jnfaV5hpAPFOYUgH2-HNKcSQCpQDL9gsyoYFBKoOolmWWAlVxU-i15l9IlZAyEeENeSwmVghn5ue-dw4i9xeJ8QDvGMPwKY-hwjN4W-zhi7HzfjD70RXDFUB5t2xhutyvs70Im9qxvC98Xy4jpT0uGjsdUHKScTLvklWvWCd8_zh3y_cvBt8VReXp2eLzYOy0tr6guJUNV10pxxXmrqXaAgssVYwgCeOusahW31DX1CuuGcl5TqipHpbAguFZ8h3yaeocYrjaYRtP5ZHG9bnoMm2RUlX3oWmZwPoE2hpQiOjNE3zVxayiYB58m-zR_febAx8fmzarD9gmfBOa1ntY3fo3b_5SZk-X5P9XllPXZ1e1Ttom_jcwqhLn4emjEgp_8WII2LPP1xGM2ee0xmmT9g_PWx_w50wb_3BX3sOyixQ</recordid><startdate>197806</startdate><enddate>197806</enddate><creator>Fink, D.W.</creator><creator>Fink, H.C.</creator><creator>Tolan, J.W.</creator><creator>Blodinger, J.</creator><general>Elsevier Inc</general><general>Wiley Subscription Services, Inc., A Wiley Company</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>197806</creationdate><title>Difference Spectrophotometric Determination of p-Hydroxybenzoic Acid in Presence of Its Esters</title><author>Fink, D.W. ; Fink, H.C. ; Tolan, J.W. ; Blodinger, J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3419-62e788773733d919f0e536b22e0503dfc7d73c1fa8be8a13381174f165c053973</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1978</creationdate><topic>difference-analysis</topic><topic>Hydroxybenzoates - analysis</topic><topic>p-hydroxybenzoic acid in presence of alkyl esters</topic><topic>p-Hydroxybenzoic acid-difference spectrophotometric analysis in presence of alkyl esters</topic><topic>Spectrophotometry</topic><topic>Spectrophotometry differenceanalysis, p-hydroxybenzoic acid in presence of alkyl esters</topic><topic>Spectrophotometry, difference—analysis, p‐hydroxybenzoic acid in presence of alkyl esters</topic><topic>Spectrophotometry, Ultraviolet - methods</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fink, D.W.</creatorcontrib><creatorcontrib>Fink, H.C.</creatorcontrib><creatorcontrib>Tolan, J.W.</creatorcontrib><creatorcontrib>Blodinger, J.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of pharmaceutical sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fink, D.W.</au><au>Fink, H.C.</au><au>Tolan, J.W.</au><au>Blodinger, J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Difference Spectrophotometric Determination of p-Hydroxybenzoic Acid in Presence of Its Esters</atitle><jtitle>Journal of pharmaceutical sciences</jtitle><addtitle>J. Pharm. Sci</addtitle><date>1978-06</date><risdate>1978</risdate><volume>67</volume><issue>6</issue><spage>837</spage><epage>839</epage><pages>837-839</pages><issn>0022-3549</issn><eissn>1520-6017</eissn><abstract>A difference spectrophotometric analytical method was developed for the selective determination of p-hydroxybenzoic acid in the presence of its alkyl esters without prior separation. Based on the spectral shift to a shorter wavelength accompanying carboxyl dissociation, the procedure measures as little as 2% of this acid in mixtures with the alkyl ester preservatives and has an accuracy of 2% mean relative error over the 0.16-12.0μg of p-hydroxybenzoic acid/ml range.</abstract><cop>Washington</cop><pub>Elsevier Inc</pub><pmid>660470</pmid><doi>10.1002/jps.2600670629</doi><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0022-3549 |
| ispartof | Journal of pharmaceutical sciences, 1978-06, Vol.67 (6), p.837-839 |
| issn | 0022-3549 1520-6017 |
| language | eng |
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| source | MEDLINE; Access via Wiley Online Library; Alma/SFX Local Collection |
| subjects | difference-analysis Hydroxybenzoates - analysis p-hydroxybenzoic acid in presence of alkyl esters p-Hydroxybenzoic acid-difference spectrophotometric analysis in presence of alkyl esters Spectrophotometry Spectrophotometry differenceanalysis, p-hydroxybenzoic acid in presence of alkyl esters Spectrophotometry, difference—analysis, p‐hydroxybenzoic acid in presence of alkyl esters Spectrophotometry, Ultraviolet - methods |
| title | Difference Spectrophotometric Determination of p-Hydroxybenzoic Acid in Presence of Its Esters |
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