Difference Spectrophotometric Determination of p-Hydroxybenzoic Acid in Presence of Its Esters
A difference spectrophotometric analytical method was developed for the selective determination of p-hydroxybenzoic acid in the presence of its alkyl esters without prior separation. Based on the spectral shift to a shorter wavelength accompanying carboxyl dissociation, the procedure measures as lit...
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Veröffentlicht in: | Journal of pharmaceutical sciences 1978-06, Vol.67 (6), p.837-839 |
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Hauptverfasser: | , , , |
Format: | Artikel |
Sprache: | eng |
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Online-Zugang: | Volltext |
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Zusammenfassung: | A difference spectrophotometric analytical method was developed for the selective determination of p-hydroxybenzoic acid in the presence of its alkyl esters without prior separation. Based on the spectral shift to a shorter wavelength accompanying carboxyl dissociation, the procedure measures as little as 2% of this acid in mixtures with the alkyl ester preservatives and has an accuracy of 2% mean relative error over the 0.16-12.0μg of p-hydroxybenzoic acid/ml range. |
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ISSN: | 0022-3549 1520-6017 |
DOI: | 10.1002/jps.2600670629 |