Difference Spectrophotometric Determination of p-Hydroxybenzoic Acid in Presence of Its Esters

A difference spectrophotometric analytical method was developed for the selective determination of p-hydroxybenzoic acid in the presence of its alkyl esters without prior separation. Based on the spectral shift to a shorter wavelength accompanying carboxyl dissociation, the procedure measures as lit...

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Veröffentlicht in:Journal of pharmaceutical sciences 1978-06, Vol.67 (6), p.837-839
Hauptverfasser: Fink, D.W., Fink, H.C., Tolan, J.W., Blodinger, J.
Format: Artikel
Sprache:eng
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Zusammenfassung:A difference spectrophotometric analytical method was developed for the selective determination of p-hydroxybenzoic acid in the presence of its alkyl esters without prior separation. Based on the spectral shift to a shorter wavelength accompanying carboxyl dissociation, the procedure measures as little as 2% of this acid in mixtures with the alkyl ester preservatives and has an accuracy of 2% mean relative error over the 0.16-12.0μg of p-hydroxybenzoic acid/ml range.
ISSN:0022-3549
1520-6017
DOI:10.1002/jps.2600670629