A Comparison between Propranolol and Hypothermia in Preventing Ischemic Contracture of the Left Ventricle (Stone Heart)
Ischemic contracture of the left ventricle (“stone heart”) was studied utilizing a previously described stone heart model. Our studies suggest that beta-adrenergic blockade is not quantitatively as important as hypothermia in protecting ischemic myocardium. On the basis of reduced fibrillatory activ...
Gespeichert in:
| Veröffentlicht in: | The Annals of thoracic surgery 1978-06, Vol.25 (6), p.541-550 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 550 |
|---|---|
| container_issue | 6 |
| container_start_page | 541 |
| container_title | The Annals of thoracic surgery |
| container_volume | 25 |
| creator | Zumbro, G. Lionel Tillman, Larry Bailey, Aubrey O. Treasure, Robert L. |
| description | Ischemic contracture of the left ventricle (“stone heart”) was studied utilizing a previously described stone heart model. Our studies suggest that beta-adrenergic blockade is not quantitatively as important as hypothermia in protecting ischemic myocardium. On the basis of reduced fibrillatory activity and a slight protective effect shown by electron microscopy, it would appear that combining propranolol with hypothermia may be superior to either used singly. |
| doi_str_mv | 10.1016/S0003-4975(10)63606-5 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_74010603</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0003497510636065</els_id><sourcerecordid>74010603</sourcerecordid><originalsourceid>FETCH-LOGICAL-c309t-b4a4c296b7ee20b1406c87e7fd68494ade4ac123bd972692d832a5b9099c403b3</originalsourceid><addsrcrecordid>eNqFkMFO3DAQhi1EgS3wBiD5hOAQajuOE5_QakW7SCsVibZXy3EmYJTYwfaCeHu8u6g99jTy_N_MyB9C55RcU0LFtwdCSFlwWVeXlFyJUhBRVHtoRquKFYJVch_N_iJH6GuMz_nJcnyIDihvmprP0NscL_w46WCjd7iF9Abg8H3wU9DOD37A2nV4-T759ARhtBrbTQyv4JJ1j_gumicYrclbXArapHUA7HucabyCPuE_GQzWDIAvH5J3gJegQ7o6QV96PUQ4_azH6Pf321-LZbH6-eNuMV8VpiQyFS3X3DAp2hqAkZZyIkxTQ913ouGS6w64NpSVbSdrJiTrmpLpqpVESsNJ2ZbH6GK3dwr-ZQ0xqdFGA8OgHfh1VDUnlAhSZrDagSb4GAP0agp21OFdUaI2vtXWt9rI3LS2vlWV584-D6zbEbp_U1vBOb7ZxZA_-WohqGgsOAOdDWCS6rz9z4EPwEKQOw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>74010603</pqid></control><display><type>article</type><title>A Comparison between Propranolol and Hypothermia in Preventing Ischemic Contracture of the Left Ventricle (Stone Heart)</title><source>MEDLINE</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Alma/SFX Local Collection</source><creator>Zumbro, G. Lionel ; Tillman, Larry ; Bailey, Aubrey O. ; Treasure, Robert L.</creator><creatorcontrib>Zumbro, G. Lionel ; Tillman, Larry ; Bailey, Aubrey O. ; Treasure, Robert L.</creatorcontrib><description>Ischemic contracture of the left ventricle (“stone heart”) was studied utilizing a previously described stone heart model. Our studies suggest that beta-adrenergic blockade is not quantitatively as important as hypothermia in protecting ischemic myocardium. On the basis of reduced fibrillatory activity and a slight protective effect shown by electron microscopy, it would appear that combining propranolol with hypothermia may be superior to either used singly.</description><identifier>ISSN: 0003-4975</identifier><identifier>EISSN: 1552-6259</identifier><identifier>DOI: 10.1016/S0003-4975(10)63606-5</identifier><identifier>PMID: 148874</identifier><language>eng</language><publisher>Netherlands: Elsevier Inc</publisher><subject>Animals ; Cardiomegaly - complications ; Coronary Disease - complications ; Coronary Disease - drug therapy ; Disease Models, Animal ; Dogs ; Heart Arrest - drug therapy ; Heart Arrest - etiology ; Heart Arrest - prevention & control ; Hypothermia, Induced ; Myocardial Contraction - drug effects ; Myocardium - ultrastructure ; Propranolol - pharmacology ; Propranolol - therapeutic use ; Ventricular Fibrillation - complications ; Ventricular Fibrillation - drug therapy</subject><ispartof>The Annals of thoracic surgery, 1978-06, Vol.25 (6), p.541-550</ispartof><rights>1978 The Society of Thoracic Surgeons</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c309t-b4a4c296b7ee20b1406c87e7fd68494ade4ac123bd972692d832a5b9099c403b3</citedby><cites>FETCH-LOGICAL-c309t-b4a4c296b7ee20b1406c87e7fd68494ade4ac123bd972692d832a5b9099c403b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/148874$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zumbro, G. Lionel</creatorcontrib><creatorcontrib>Tillman, Larry</creatorcontrib><creatorcontrib>Bailey, Aubrey O.</creatorcontrib><creatorcontrib>Treasure, Robert L.</creatorcontrib><title>A Comparison between Propranolol and Hypothermia in Preventing Ischemic Contracture of the Left Ventricle (Stone Heart)</title><title>The Annals of thoracic surgery</title><addtitle>Ann Thorac Surg</addtitle><description>Ischemic contracture of the left ventricle (“stone heart”) was studied utilizing a previously described stone heart model. Our studies suggest that beta-adrenergic blockade is not quantitatively as important as hypothermia in protecting ischemic myocardium. On the basis of reduced fibrillatory activity and a slight protective effect shown by electron microscopy, it would appear that combining propranolol with hypothermia may be superior to either used singly.</description><subject>Animals</subject><subject>Cardiomegaly - complications</subject><subject>Coronary Disease - complications</subject><subject>Coronary Disease - drug therapy</subject><subject>Disease Models, Animal</subject><subject>Dogs</subject><subject>Heart Arrest - drug therapy</subject><subject>Heart Arrest - etiology</subject><subject>Heart Arrest - prevention & control</subject><subject>Hypothermia, Induced</subject><subject>Myocardial Contraction - drug effects</subject><subject>Myocardium - ultrastructure</subject><subject>Propranolol - pharmacology</subject><subject>Propranolol - therapeutic use</subject><subject>Ventricular Fibrillation - complications</subject><subject>Ventricular Fibrillation - drug therapy</subject><issn>0003-4975</issn><issn>1552-6259</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1978</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMFO3DAQhi1EgS3wBiD5hOAQajuOE5_QakW7SCsVibZXy3EmYJTYwfaCeHu8u6g99jTy_N_MyB9C55RcU0LFtwdCSFlwWVeXlFyJUhBRVHtoRquKFYJVch_N_iJH6GuMz_nJcnyIDihvmprP0NscL_w46WCjd7iF9Abg8H3wU9DOD37A2nV4-T759ARhtBrbTQyv4JJ1j_gumicYrclbXArapHUA7HucabyCPuE_GQzWDIAvH5J3gJegQ7o6QV96PUQ4_azH6Pf321-LZbH6-eNuMV8VpiQyFS3X3DAp2hqAkZZyIkxTQ913ouGS6w64NpSVbSdrJiTrmpLpqpVESsNJ2ZbH6GK3dwr-ZQ0xqdFGA8OgHfh1VDUnlAhSZrDagSb4GAP0agp21OFdUaI2vtXWt9rI3LS2vlWV584-D6zbEbp_U1vBOb7ZxZA_-WohqGgsOAOdDWCS6rz9z4EPwEKQOw</recordid><startdate>197806</startdate><enddate>197806</enddate><creator>Zumbro, G. Lionel</creator><creator>Tillman, Larry</creator><creator>Bailey, Aubrey O.</creator><creator>Treasure, Robert L.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>197806</creationdate><title>A Comparison between Propranolol and Hypothermia in Preventing Ischemic Contracture of the Left Ventricle (Stone Heart)</title><author>Zumbro, G. Lionel ; Tillman, Larry ; Bailey, Aubrey O. ; Treasure, Robert L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c309t-b4a4c296b7ee20b1406c87e7fd68494ade4ac123bd972692d832a5b9099c403b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1978</creationdate><topic>Animals</topic><topic>Cardiomegaly - complications</topic><topic>Coronary Disease - complications</topic><topic>Coronary Disease - drug therapy</topic><topic>Disease Models, Animal</topic><topic>Dogs</topic><topic>Heart Arrest - drug therapy</topic><topic>Heart Arrest - etiology</topic><topic>Heart Arrest - prevention & control</topic><topic>Hypothermia, Induced</topic><topic>Myocardial Contraction - drug effects</topic><topic>Myocardium - ultrastructure</topic><topic>Propranolol - pharmacology</topic><topic>Propranolol - therapeutic use</topic><topic>Ventricular Fibrillation - complications</topic><topic>Ventricular Fibrillation - drug therapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zumbro, G. Lionel</creatorcontrib><creatorcontrib>Tillman, Larry</creatorcontrib><creatorcontrib>Bailey, Aubrey O.</creatorcontrib><creatorcontrib>Treasure, Robert L.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Annals of thoracic surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zumbro, G. Lionel</au><au>Tillman, Larry</au><au>Bailey, Aubrey O.</au><au>Treasure, Robert L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A Comparison between Propranolol and Hypothermia in Preventing Ischemic Contracture of the Left Ventricle (Stone Heart)</atitle><jtitle>The Annals of thoracic surgery</jtitle><addtitle>Ann Thorac Surg</addtitle><date>1978-06</date><risdate>1978</risdate><volume>25</volume><issue>6</issue><spage>541</spage><epage>550</epage><pages>541-550</pages><issn>0003-4975</issn><eissn>1552-6259</eissn><abstract>Ischemic contracture of the left ventricle (“stone heart”) was studied utilizing a previously described stone heart model. Our studies suggest that beta-adrenergic blockade is not quantitatively as important as hypothermia in protecting ischemic myocardium. On the basis of reduced fibrillatory activity and a slight protective effect shown by electron microscopy, it would appear that combining propranolol with hypothermia may be superior to either used singly.</abstract><cop>Netherlands</cop><pub>Elsevier Inc</pub><pmid>148874</pmid><doi>10.1016/S0003-4975(10)63606-5</doi><tpages>10</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0003-4975 |
| ispartof | The Annals of thoracic surgery, 1978-06, Vol.25 (6), p.541-550 |
| issn | 0003-4975 1552-6259 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_74010603 |
| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Animals Cardiomegaly - complications Coronary Disease - complications Coronary Disease - drug therapy Disease Models, Animal Dogs Heart Arrest - drug therapy Heart Arrest - etiology Heart Arrest - prevention & control Hypothermia, Induced Myocardial Contraction - drug effects Myocardium - ultrastructure Propranolol - pharmacology Propranolol - therapeutic use Ventricular Fibrillation - complications Ventricular Fibrillation - drug therapy |
| title | A Comparison between Propranolol and Hypothermia in Preventing Ischemic Contracture of the Left Ventricle (Stone Heart) |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-29T02%3A41%3A20IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=A%20Comparison%20between%20Propranolol%20and%20Hypothermia%20in%20Preventing%20Ischemic%20Contracture%20of%20the%20Left%20Ventricle%20(Stone%20Heart)&rft.jtitle=The%20Annals%20of%20thoracic%20surgery&rft.au=Zumbro,%20G.%20Lionel&rft.date=1978-06&rft.volume=25&rft.issue=6&rft.spage=541&rft.epage=550&rft.pages=541-550&rft.issn=0003-4975&rft.eissn=1552-6259&rft_id=info:doi/10.1016/S0003-4975(10)63606-5&rft_dat=%3Cproquest_cross%3E74010603%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=74010603&rft_id=info:pmid/148874&rft_els_id=S0003497510636065&rfr_iscdi=true |