A Comparison between Propranolol and Hypothermia in Preventing Ischemic Contracture of the Left Ventricle (Stone Heart)

Ischemic contracture of the left ventricle (“stone heart”) was studied utilizing a previously described stone heart model. Our studies suggest that beta-adrenergic blockade is not quantitatively as important as hypothermia in protecting ischemic myocardium. On the basis of reduced fibrillatory activ...

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Veröffentlicht in:	The Annals of thoracic surgery 1978-06, Vol.25 (6), p.541-550
Hauptverfasser:	Zumbro, G. Lionel, Tillman, Larry, Bailey, Aubrey O., Treasure, Robert L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cardiomegaly - complications Coronary Disease - complications Coronary Disease - drug therapy Disease Models, Animal Dogs Heart Arrest - drug therapy Heart Arrest - etiology Heart Arrest - prevention & control Hypothermia, Induced Myocardial Contraction - drug effects Myocardium - ultrastructure Propranolol - pharmacology Propranolol - therapeutic use Ventricular Fibrillation - complications Ventricular Fibrillation - drug therapy
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Beschreibung
Zusammenfassung:	Ischemic contracture of the left ventricle (“stone heart”) was studied utilizing a previously described stone heart model. Our studies suggest that beta-adrenergic blockade is not quantitatively as important as hypothermia in protecting ischemic myocardium. On the basis of reduced fibrillatory activity and a slight protective effect shown by electron microscopy, it would appear that combining propranolol with hypothermia may be superior to either used singly.
ISSN:	0003-4975 1552-6259
DOI:	10.1016/S0003-4975(10)63606-5