“B-cell” mitogenicity of carragheenan in mouse

Carragheenan, a reported toxic agent for macrophages, has been studied for its properties of stimulation of mouse lymphocytes, by measuring the amount of incorporation of tritiated thymidine in cultures of lymphocytes in vitro. Unequivocal evidence has been obtained, concluding that carragheenan sel...

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Veröffentlicht in:	Cellular immunology 1978-04, Vol.37 (1), p.1-13
Hauptverfasser:	Quan, Phuc Canh, Kolb, Jean-Pierre B., Lespinats, Geneviève
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals B-Lymphocytes - drug effects B-Lymphocytes - immunology Bone Marrow - immunology Carrageenan - pharmacology Dose-Response Relationship, Drug Lymphocyte Activation - drug effects Macrophages - immunology Mice Mice, Inbred Strains - immunology Species Specificity Spleen - immunology T-Lymphocytes - immunology Thymus Gland - immunology
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Zusammenfassung:	Carragheenan, a reported toxic agent for macrophages, has been studied for its properties of stimulation of mouse lymphocytes, by measuring the amount of incorporation of tritiated thymidine in cultures of lymphocytes in vitro. Unequivocal evidence has been obtained, concluding that carragheenan selectively activates mouse “B” cells from each strain tested, with the exception of C3H/He mice. Carragheenan probably acts on a subpopulation of B cells different from the populations stimulated by dextran sulfate and LPS.
ISSN:	0008-8749 1090-2163
DOI:	10.1016/0008-8749(78)90168-5