Quantitative Analysis of Ethynodiol Diacetate and Ethinyl Estradiol/Mestranol in Oral Contraceptive Tablets by High-Performance Liquid Chromatography

A procedure is described for the assay of ethynodiol diacetate and ethinyl estradiol/mestranol by HPLC using two UV detectors at 210 and 280 nm. The system was acetonitrile 38% (v/v) in water as mobile phase on a 250 X 3.2-mm i.d. RP-2 column, with butylated hydroxyto-luene as the internal standard....

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Veröffentlicht in:	Journal of pharmaceutical sciences 1982-02, Vol.71 (2), p.264-266
Hauptverfasser:	Carignan, G., Lodge, B.A., Skakum, W.
Format:	Artikel
Sprache:	eng
Schlagworte:	and mestranol by high-performance liquid chromatography and mestranol in oral contraceptive tablets Chromatography, High Pressure Liquid - methods Contraceptives, Oral - analysis Contraceptives, Oral, Combined - analysis estradiol Ethinyl Estradiol - analysis Ethinyl estradiol-quantitative analysis by high-performance liquid chromatography Ethinyl estradiol—quantitative analysis by high‐performance liquid chromatography, oral contraceptive tablets Ethynodiol Diacetate - analysis Ethynodiol-quantitative analysis by high-performance liquid chromatography Ethynodiol—quantitative analysis by high‐performance liquid chromatography, oral contraceptive tablets High-performance liquid chromatography-quantitative analysis of ethynodiol High‐performance liquid chromatography—quantitative analysis of ethynodiol, estradiol, and mestranol in oral contraceptive tablets Mestranol - analysis Mestranol-quantitative analysis by high-performance liquid chromatography Mestranol—quantitative analysis by high‐performance liquid chromatography, oral contraceptive tablets oral contraceptive tablets Oral contraceptives-quantitative analysis of ethynodiol Oral contraceptives—quantitative analysis of ethynodiol, estradiol, and mestranol by high‐performance liquid chromatography Population Spectrophotometry, Ultraviolet - methods Tablets - analysis
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Beschreibung
Zusammenfassung:	A procedure is described for the assay of ethynodiol diacetate and ethinyl estradiol/mestranol by HPLC using two UV detectors at 210 and 280 nm. The system was acetonitrile 38% (v/v) in water as mobile phase on a 250 X 3.2-mm i.d. RP-2 column, with butylated hydroxyto-luene as the internal standard. There was >99% recovery from synthetic preparations and the coefficient of variation was
ISSN:	0022-3549 1520-6017
DOI:	10.1002/jps.2600710231