VARIATION OF INTESTINAL BACTERIA DURING ADMINISTRATION OF IMMUNOSUPPRESSIVE DRUGS AND ANTICANCER DRUGS (I)

Some studies have been reported for intestinal bacteria in patients with immunoinsufficiency, but further examination would be required. In this study, the variations of intestinal bacteria in feces during administration of immunosuppressive drugs or anticancer drugs were examined for experimental animals and some clinical cases with malignant tumor. Intestinal bacteria in feces were isolated in aerobic or anaerobic conditions. As aerobic bacteria, Lactobacillus, E.coli, and Str.faecalis, as anaerobic, L.bifidus, Bacteroides, Peptostreptococcus, and Veillonella were chiefly isolated. By administration of steroid hormone, number of E.coli, Bacteroides and some enterobacteria in feces increased remarkably, and then after suspension of drug administration, original population of intestinal microflora was observed again 2 or 3 weeks later. Anticancer drugs such as 6 Mercaptopurine, 5 Fluorouracil, Azathiopurine were also resulted in fair increase of enterobacteria. The effect by Cyclophosphamide, Busulfan and Mitomycin C was not so remarkable compared with other drugs. By administration of these drugs, variations of constant intestinal microflora were observed. Therefore, it was demonstrated that the secondary disturbances in intestinal tract (for instance, increases of some amines produced by enterobacteria) would be appeared during therapy by various immunosuppressive drugs.