Prostaglandin-induced eosinopenia in splenectomized rats

Prostaglandin-induced eosinopenia in splenectomized rats

PGE 1 , PGE 2 , and PGF 2α over a dose range of 1 to 50 μ/kg decreased the number of circulating eosinophils in splenectomized rats. Pretreatment with a β-blocking agent, propranolol, did not alter this effect, but adrenalectomy eliminated it. Anterior hypothalamic destruction also abolished eosinop...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Journal of allergy and clinical immunology 1978-07, Vol.62 (1), p.33-36
Hauptverfasser: Kurosawa, Motohiro, Nemoto, Toshikazu, Aoki, Hideo, Ike, Aiko, Abe, Osamu, Sunaga, Yoshinobu, Kobayashi, Setsuo
Format: Artikel
Sprache:eng
Schlagworte:
Adrenalectomy
Animals
Eosinophils
Epinephrine - pharmacology
Hypothalamus, Anterior - physiology
Leukocyte Count
Leukopenia - physiopathology
Male
Propranolol - pharmacology
Prostaglandins - physiology
Prostaglandins E - pharmacology
Prostaglandins F - pharmacology
Rats
Splenectomy
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:PGE 1 , PGE 2 , and PGF 2α over a dose range of 1 to 50 μ/kg decreased the number of circulating eosinophils in splenectomized rats. Pretreatment with a β-blocking agent, propranolol, did not alter this effect, but adrenalectomy eliminated it. Anterior hypothalamic destruction also abolished eosinopenia induced by PGE 1 and PGF 2α but not that induced by PGE 2 .
ISSN:0091-6749
1097-6825
DOI:10.1016/0091-6749(78)90070-2