Effects of trace elements and mono- and dithiols on mitochondrial monoamine oxidase of rats

The effects of several trace elements on mitochondrial monoamine oxidase (MAO) were studied. Elements were studied at a concentration of 1 m m; only mercury, cadmium, and copper were significantly effective in reducing the activity of this enzyme. Of several thiols tested, only dithiothreitol could...

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Veröffentlicht in:	Toxicol. Appl. Pharmacol.; (United States) 1978-03, Vol.43 (3), p.439-448
Hauptverfasser:	Revis, Nathaniel, Horton, Carol
Format:	Artikel
Sprache:	eng
Schlagworte:	550200 - Biochemistry 550500 - Metabolism 560305 - Chemicals Metabolism & Toxicology- Vertebrates- (-1987) Adrenal Glands - enzymology AMINO ACIDS ANIMALS BASIC BIOLOGICAL SCIENCES BIOCHEMICAL REACTION KINETICS Brain - enzymology CADMIUM CARBOXYLIC ACIDS CELL CONSTITUENTS COPPER CYSTEINE ELEMENTS Enzyme Activation - drug effects ENZYMES GLUTATHIONE HOMOCYSTEINE In Vitro Techniques INHIBITION Kidney - enzymology KINETICS Liver - enzymology Male MAMMALS MERCURY METALS MITOCHONDRIA Mitochondria, Liver - enzymology Monoamine Oxidase Inhibitors Myocardium - enzymology ORGANIC ACIDS ORGANIC COMPOUNDS ORGANIC SULFUR COMPOUNDS ORGANOIDS OXIDASES OXIDOREDUCTASES PEPTIDES POLLUTION POLYPEPTIDES PROTEINS RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT RATS REACTION KINETICS RODENTS Sulfhydryl Compounds - pharmacology THIOLS Trace Elements - pharmacology TRANSITION ELEMENTS VERTEBRATES
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Zusammenfassung:	The effects of several trace elements on mitochondrial monoamine oxidase (MAO) were studied. Elements were studied at a concentration of 1 m m; only mercury, cadmium, and copper were significantly effective in reducing the activity of this enzyme. Of several thiols tested, only dithiothreitol could reverse the inhibition of MAO by these elements. Evidence is also presented in this report to show that cysteine, homocysteine, and reduced glutathione inhibit this MAO, whereas dithiothreitol or dithioerythritol evoke stimulatory responses.
ISSN:	0041-008X 1096-0333
DOI:	10.1016/S0041-008X(78)80003-9