EFFECT OF PREANAESTHETIC MEDICATION ON ANAESTHESIA WITH ICI 35 868

The effect of three commonly used premcdicants and a control on anaesthesia with ICI 35 868 is described Two randomized studies were performed-one a group study of induction characteristics at 2mgkg−1 and the other a detailed study in patients undergoing minor gynaecological surgery with an induction dose of 1.5mgkg−1 and maintenance with incremental doses plus 66% nitrous oxide in oxygen Premedication had little effect on the already good induction characteristics. Only heavy opiate premedication produced reliable induction at 1 5 mg kg−1, but with an increase in side-effects Diazepam appears to be the premedicant of choice, although the overall frequency of pain on injection has not been affected by premedication.