The analog free testosterone assay: are the results in men clinically useful?

Men with low testosterone concentrations are usually hypogonadal. However, because variations in the testosterone transport protein, sex hormone-binding globulin (SHBG), directly influence the total testosterone concentration, confirmation of a low testosterone with a measurement of free testosteron...

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Veröffentlicht in:Clinical chemistry (Baltimore, Md.) Md.), 1998-10, Vol.44 (10), p.2178-2182
Hauptverfasser: Winters, Stephen J, Kelley, David E, Goodpaster, Bret
Format: Artikel
Sprache:eng
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Zusammenfassung:Men with low testosterone concentrations are usually hypogonadal. However, because variations in the testosterone transport protein, sex hormone-binding globulin (SHBG), directly influence the total testosterone concentration, confirmation of a low testosterone with a measurement of free testosterone or "bioavailable" testosterone (BAT) is recommended. In the present study, we examined the relationship of SHBG with free testosterone (Coat-A-Count assay, Diagnostic Products) and with BAT in men (n = 29) and women (n = 28) who participated in a study of the metabolic determinants of body composition. As expected, total testosterone was strongly positively correlated with SHBG among men (r = 0.68; P
ISSN:0009-9147
1530-8561
DOI:10.1093/clinchem/44.10.2178