Clinical and Serological Evaluation of a Meningococcal Polysaccharide Vaccine Groups A, C, Y, and W135

Abstract The clinical evaluation of a meningococcal polysaccharide vaccine containing groups A, C, Y, and W135 antigens was described. The vaccine was found to be clinically acceptable and a significant antibody response was detected by both a bactericidal assay and a solid-phase radioimmune assay.

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Bibliographische Detailangaben
Veröffentlicht in:	Experimental biology and medicine (Maywood, N.J.) N.J.), 1982-01, Vol.169 (1), p.54-057
Hauptverfasser:	Hankins, William A., Gwaltney, Jack M., Hendley, J. Owen, Farquhar, John D., Samuelson, Joel S.
Format:	Artikel
Sprache:	eng
Schlagworte:	550601 - Medicine- Unsealed Radionuclides in Diagnostics Adolescent Adult Antibodies, Bacterial - biosynthesis ANTIGENS BACTERIA Bacterial Vaccines - adverse effects Bacterial Vaccines - standards Bacterial Vaccines - therapeutic use Blood Bactericidal Activity CARBOHYDRATES EVALUATION Female Humans IMMUNE REACTIONS ISOTOPE APPLICATIONS Male Meningococcal Infections - prevention & control MENINGOCOCCUS MICROORGANISMS Neisseria meningitidis Neisseria meningitidis - immunology ORGANIC COMPOUNDS POLYSACCHARIDES Polysaccharides, Bacterial - standards Polysaccharides, Bacterial - therapeutic use RADIOASSAY RADIOIMMUNOASSAY RADIOLOGY AND NUCLEAR MEDICINE SACCHARIDES TRACER TECHNIQUES VACCINES
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Beschreibung
Zusammenfassung:	Abstract The clinical evaluation of a meningococcal polysaccharide vaccine containing groups A, C, Y, and W135 antigens was described. The vaccine was found to be clinically acceptable and a significant antibody response was detected by both a bactericidal assay and a solid-phase radioimmune assay.
ISSN:	0037-9727 1535-3702 1535-3699
DOI:	10.3181/00379727-169-41306