Effects of Anticonvulsants on the Formation of γ‐Hydroxybutyrate from γ‐Aminobutyrate in Rat Brain
: The conversion of γ‐aminobutyrate (GABA) via succinic semialdehyde to γ‐hydroxybutyrate has been examined in rat brain homogenates. A number of anticonvulsants, including sodium valproate and phenobarbitone, inhibited this metabolic pathway. These results are interpreted in the light of the charac...
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| Veröffentlicht in: | Journal of neurochemistry 1982-03, Vol.38 (3), p.848-851 |
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| container_title | Journal of neurochemistry |
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| creator | Whittle, Susan R. Turner, Anthony J. |
| description | : The conversion of γ‐aminobutyrate (GABA) via succinic semialdehyde to γ‐hydroxybutyrate has been examined in rat brain homogenates. A number of anticonvulsants, including sodium valproate and phenobarbitone, inhibited this metabolic pathway. These results are interpreted in the light of the characteristics of aldehyde reductases known to reduce succinic semialdehyde. |
| doi_str_mv | 10.1111/j.1471-4159.1982.tb08710.x |
| format | Article |
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A number of anticonvulsants, including sodium valproate and phenobarbitone, inhibited this metabolic pathway. These results are interpreted in the light of the characteristics of aldehyde reductases known to reduce succinic semialdehyde.</description><identifier>ISSN: 0022-3042</identifier><identifier>EISSN: 1471-4159</identifier><identifier>DOI: 10.1111/j.1471-4159.1982.tb08710.x</identifier><identifier>PMID: 7057198</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>4-Aminobutyrate Transaminase - metabolism ; Aldehyde reductase ; Animals ; Anticonvulsants ; Anticonvulsants - pharmacology ; Brain - drug effects ; Brain - metabolism ; GABA metabolism ; gamma-Aminobutyric Acid - biosynthesis ; Hydroxybutyrates - biosynthesis ; Male ; Rats ; Rats, Inbred Strains ; Sodium Oxybate ; Sodium valproate ; Structure-Activity Relationship ; Succinic semialdehyde ; γ‐Hydroxybutyrate</subject><ispartof>Journal of neurochemistry, 1982-03, Vol.38 (3), p.848-851</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3698-c81c6ab1956e511d8b8347cd37c5ebf89ca56a14fdcdd10436e4cba2ed5641383</citedby><cites>FETCH-LOGICAL-c3698-c81c6ab1956e511d8b8347cd37c5ebf89ca56a14fdcdd10436e4cba2ed5641383</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1471-4159.1982.tb08710.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1471-4159.1982.tb08710.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,781,785,1418,27928,27929,45578,45579</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7057198$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Whittle, Susan R.</creatorcontrib><creatorcontrib>Turner, Anthony J.</creatorcontrib><title>Effects of Anticonvulsants on the Formation of γ‐Hydroxybutyrate from γ‐Aminobutyrate in Rat Brain</title><title>Journal of neurochemistry</title><addtitle>J Neurochem</addtitle><description>: The conversion of γ‐aminobutyrate (GABA) via succinic semialdehyde to γ‐hydroxybutyrate has been examined in rat brain homogenates. 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These results are interpreted in the light of the characteristics of aldehyde reductases known to reduce succinic semialdehyde.</description><subject>4-Aminobutyrate Transaminase - metabolism</subject><subject>Aldehyde reductase</subject><subject>Animals</subject><subject>Anticonvulsants</subject><subject>Anticonvulsants - pharmacology</subject><subject>Brain - drug effects</subject><subject>Brain - metabolism</subject><subject>GABA metabolism</subject><subject>gamma-Aminobutyric Acid - biosynthesis</subject><subject>Hydroxybutyrates - biosynthesis</subject><subject>Male</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Sodium Oxybate</subject><subject>Sodium valproate</subject><subject>Structure-Activity Relationship</subject><subject>Succinic semialdehyde</subject><subject>γ‐Hydroxybutyrate</subject><issn>0022-3042</issn><issn>1471-4159</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1982</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkEFKxDAUhoMoOo4eQSgu3HXMa9I0dSGMgzqKKIiuQ5qm2KFtNEl1uvMI3sV7eAhPYssMszebkPf9_wt8CB0DnkB_ThcToAmEFOJ0AimPJj7DPOnpcguNNmgbjTCOopBgGu2hfecWGAOjDHbRboLjpG-O0MtlUWjlXWCKYNr4Upnmva2cbIZRE_gXHVwZW0tf9q8-8_P9-_k173Jrll3W-s5Kr4PCmnpFpnXZmM28bIJH6YMLK8vmAO0UsnL6cH2P0fPV5dNsHt49XN_MpnehIizloeKgmMwgjZmOAXKecUITlZNExToreKpkzCTQIld5DpgSpqnKZKTzmFEgnIzRyWrvqzVvrXZe1KVTuqpko03rREJSBjiBPni2CiprnLO6EK-2rKXtBGAxaBYLMbgUg0sxaBZrzWLZl4_Wv7RZrfNNde215-cr_lFWuvvHZnF7P-OUkz9eRJJG</recordid><startdate>198203</startdate><enddate>198203</enddate><creator>Whittle, Susan R.</creator><creator>Turner, Anthony J.</creator><general>Blackwell Publishing Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198203</creationdate><title>Effects of Anticonvulsants on the Formation of γ‐Hydroxybutyrate from γ‐Aminobutyrate in Rat Brain</title><author>Whittle, Susan R. ; Turner, Anthony J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3698-c81c6ab1956e511d8b8347cd37c5ebf89ca56a14fdcdd10436e4cba2ed5641383</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1982</creationdate><topic>4-Aminobutyrate Transaminase - metabolism</topic><topic>Aldehyde reductase</topic><topic>Animals</topic><topic>Anticonvulsants</topic><topic>Anticonvulsants - pharmacology</topic><topic>Brain - drug effects</topic><topic>Brain - metabolism</topic><topic>GABA metabolism</topic><topic>gamma-Aminobutyric Acid - biosynthesis</topic><topic>Hydroxybutyrates - biosynthesis</topic><topic>Male</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Sodium Oxybate</topic><topic>Sodium valproate</topic><topic>Structure-Activity Relationship</topic><topic>Succinic semialdehyde</topic><topic>γ‐Hydroxybutyrate</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Whittle, Susan R.</creatorcontrib><creatorcontrib>Turner, Anthony J.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of neurochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Whittle, Susan R.</au><au>Turner, Anthony J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of Anticonvulsants on the Formation of γ‐Hydroxybutyrate from γ‐Aminobutyrate in Rat Brain</atitle><jtitle>Journal of neurochemistry</jtitle><addtitle>J Neurochem</addtitle><date>1982-03</date><risdate>1982</risdate><volume>38</volume><issue>3</issue><spage>848</spage><epage>851</epage><pages>848-851</pages><issn>0022-3042</issn><eissn>1471-4159</eissn><abstract>: The conversion of γ‐aminobutyrate (GABA) via succinic semialdehyde to γ‐hydroxybutyrate has been examined in rat brain homogenates. 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| identifier | ISSN: 0022-3042 |
| ispartof | Journal of neurochemistry, 1982-03, Vol.38 (3), p.848-851 |
| issn | 0022-3042 1471-4159 |
| language | eng |
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| source | MEDLINE; Access via Wiley Online Library |
| subjects | 4-Aminobutyrate Transaminase - metabolism Aldehyde reductase Animals Anticonvulsants Anticonvulsants - pharmacology Brain - drug effects Brain - metabolism GABA metabolism gamma-Aminobutyric Acid - biosynthesis Hydroxybutyrates - biosynthesis Male Rats Rats, Inbred Strains Sodium Oxybate Sodium valproate Structure-Activity Relationship Succinic semialdehyde γ‐Hydroxybutyrate |
| title | Effects of Anticonvulsants on the Formation of γ‐Hydroxybutyrate from γ‐Aminobutyrate in Rat Brain |
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