Effects of Anticonvulsants on the Formation of γ‐Hydroxybutyrate from γ‐Aminobutyrate in Rat Brain

: The conversion of γ‐aminobutyrate (GABA) via succinic semialdehyde to γ‐hydroxybutyrate has been examined in rat brain homogenates. A number of anticonvulsants, including sodium valproate and phenobarbitone, inhibited this metabolic pathway. These results are interpreted in the light of the charac...

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Veröffentlicht in:	Journal of neurochemistry 1982-03, Vol.38 (3), p.848-851
Hauptverfasser:	Whittle, Susan R., Turner, Anthony J.
Format:	Artikel
Sprache:	eng
Schlagworte:	4-Aminobutyrate Transaminase - metabolism Aldehyde reductase Animals Anticonvulsants Anticonvulsants - pharmacology Brain - drug effects Brain - metabolism GABA metabolism gamma-Aminobutyric Acid - biosynthesis Hydroxybutyrates - biosynthesis Male Rats Rats, Inbred Strains Sodium Oxybate Sodium valproate Structure-Activity Relationship Succinic semialdehyde γ‐Hydroxybutyrate
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Beschreibung
Zusammenfassung:	: The conversion of γ‐aminobutyrate (GABA) via succinic semialdehyde to γ‐hydroxybutyrate has been examined in rat brain homogenates. A number of anticonvulsants, including sodium valproate and phenobarbitone, inhibited this metabolic pathway. These results are interpreted in the light of the characteristics of aldehyde reductases known to reduce succinic semialdehyde.
ISSN:	0022-3042 1471-4159
DOI:	10.1111/j.1471-4159.1982.tb08710.x