Placental transfer of ritonavir with zidovudine in the ex vivo placental perfusion model

Placental transfer of ritonavir with zidovudine in the ex vivo placental perfusion model

OBJECTIVE: The object was to determine the placental transfer of ritonavir alone and in combination with zidovudine. STUDY DESIGN: Twelve placental perfusion studies were performed at trough (1-2 μg/mL) and peak (~20 μg/mL) combinations of ritonavir and zidovudine. Accumulation of ritonavir was dete...

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Veröffentlicht in:American journal of obstetrics and gynecology 1998-09, Vol.179 (3), p.758-761
Hauptverfasser: Casey, Brian M., Bawdon, Roger E.
Format: Artikel
Sprache:eng
Schlagworte:
AIDS/HIV
Anti-HIV Agents - pharmacokinetics
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antiviral agents
Biological and medical sciences
Drug Combinations
Ex vivo
Female
HIV Protease Inhibitors - pharmacokinetics
Humans
Maternal-Fetal Exchange
Medical sciences
Osmolar Concentration
Perfusion
Pharmacology. Drug treatments
Placenta - metabolism
placental transfer
Pregnancy
protease inhibitor
Reproducibility of Results
Ritonavir - pharmacokinetics
Zidovudine - pharmacokinetics
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Zusammenfassung:OBJECTIVE: The object was to determine the placental transfer of ritonavir alone and in combination with zidovudine. STUDY DESIGN: Twelve placental perfusion studies were performed at trough (1-2 μg/mL) and peak (~20 μg/mL) combinations of ritonavir and zidovudine. Accumulation of ritonavir was determined. RESULTS: Transfer of ritonavir at trough concentrations was undetectable (
ISSN:0002-9378
1097-6868
DOI:10.1016/S0002-9378(98)70078-X