The Genome of Simian Virus 40

The Genome of Simian Virus 40

The nucleotide sequence of SV40 DNA was determined, and the sequence was correlated with known genes of the virus and with the structure of viral messenger RNA's. There is a limited overlap of the coding regions for structural proteins and a complex pattern of leader sequences at the 5′ end of...

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Veröffentlicht in:Science (American Association for the Advancement of Science) 1978-05, Vol.200 (4341), p.494-502
Hauptverfasser: Reddy, V. B., Thimmappaya, B., Dhar, R., Subramanian, K. N., Zain, B. S., Pan, J., Ghosh, P. K., Celma, M. L., Weissman, S. M.
Format: Artikel
Sprache:eng
Schlagworte:
Base Sequence
Chromosome Mapping
Codon
Codons
DNA
DNA Replication
DNA, Circular
DNA, Viral
Genes
Genes, Viral
Genomes
Messenger RNA
Nucleotide sequences
Open reading frames
Replication origin
RNA
Simian virus 40 - genetics
Simian viruses
Terminator regions
Transcription, Genetic
Viral Proteins - genetics
Viruses
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Beschreibung
Zusammenfassung:The nucleotide sequence of SV40 DNA was determined, and the sequence was correlated with known genes of the virus and with the structure of viral messenger RNA's. There is a limited overlap of the coding regions for structural proteins and a complex pattern of leader sequences at the 5′ end of late messenger RNA. The sequence of the early region is consistent with recent proposals that the large early polypeptide of SV40 is encoded in noncontiguous segments of DNA.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.205947