Conformationally Constrained 1,3-Diamino Ketones: A Series of Potent Inhibitors of the Cysteine Protease Cathepsin K

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Veröffentlicht in:	Journal of medicinal chemistry 1998-09, Vol.41 (19), p.3563-3567
Hauptverfasser:	Marquis, Robert W, Yamashita, Dennis S, Ru, Yu, LoCastro, Stephen M, Oh, Hye-Ja, Erhard, Karl F, DesJarlais, Renee L, Head, Martha S, Smith, Ward W, Zhao, Baoguang, Janson, Cheryl A, Abdel-Meguid, Sherin S, Tomaszek, Thaddeus A, Levy, Mark A, Veber, Daniel F
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding Sites Biological and medical sciences Bones, joints and connective tissue. Antiinflammatory agents Cathepsin K Cathepsins - antagonists & inhibitors Cathepsins - metabolism Crystallography, X-Ray Cysteine Proteinase Inhibitors - chemical synthesis Cysteine Proteinase Inhibitors - chemistry Cysteine Proteinase Inhibitors - metabolism Cysteine Proteinase Inhibitors - pharmacology Diamines - chemical synthesis Diamines - chemistry Diamines - pharmacology Ketones - chemical synthesis Ketones - chemistry Ketones - pharmacology Medical sciences Models, Molecular Molecular Conformation Molecular Mimicry Peptides - chemistry Pharmacology. Drug treatments Stereoisomerism Structure-Activity Relationship
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