Negative association between asthma and variants of CC16(CC10) on chromosome 11q13 in British and Japanese populations

The gene encoding Clara cell-derived inflammatory molecule CC16 has been cited as a candidate gene for atopic asthma on chromosome 1lq13. A genetic association study was performed with variants of the CC16 gene on chromosome 1lq13 in relation to asthma in British (n=275) and Japanese (n=300) populat...

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Veröffentlicht in:	Human genetics 1998-07, Vol.103 (1), p.57-59
Hauptverfasser:	GAO, P.-S, MAO, X.-Q, COULL, P, SHIRAKAWA, T, HOPKIN, J. M, KAWAI, M, ENOMOTO, T, SASAKI, S, TANABE, O, YOSHIMURA, K, SHALDON, S. R, DAKE, Y, KITANO, H
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergic diseases Asthma - classification Asthma - genetics Biological and medical sciences Chromosome Mapping Chromosomes, Human, Pair 11 Genetic Variation Genotype Humans Immunopathology Japan Medical sciences Odds Ratio Polymerase Chain Reaction Proteins - genetics Reference Values Respiratory and ent allergic diseases Risk Assessment United Kingdom Uteroglobin
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Zusammenfassung:	The gene encoding Clara cell-derived inflammatory molecule CC16 has been cited as a candidate gene for atopic asthma on chromosome 1lq13. A genetic association study was performed with variants of the CC16 gene on chromosome 1lq13 in relation to asthma in British (n=275) and Japanese (n=300) populations. No significant association was found between asthma and CC16 genotypes, irrespective of atopic status in these two populations. These data suggest that CC16 might not be the major locus for asthma on 11q13.
ISSN:	0340-6717 1432-1203
DOI:	10.1007/s004390050783